PF4 and CXCL12 |
platelet factor 4 |
chemokine (C-X-C motif) ligand 12 |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- Class A/1 (Rhodopsin-like receptors)
- Platelet degranulation
- GPCR ligand binding
- Metabolic disorders of biological oxidation enzymes
- Formation of Fibrin Clot (Clotting Cascade)
- Cell surface interactions at the vascular wall
- Common Pathway
- GPCR downstream signaling
- Peptide ligand-binding receptors
- Chemokine receptors bind chemokines
- Response to elevated platelet cytosolic Ca2+
- G alpha (i) signalling events
- Platelet activation, signaling and aggregation
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- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- Class A/1 (Rhodopsin-like receptors)
- Signaling by ERBB4
- GPCR ligand binding
- Metabolic disorders of biological oxidation enzymes
- GPCR downstream signaling
- Nuclear signaling by ERBB4
- Peptide ligand-binding receptors
- Chemokine receptors bind chemokines
- G alpha (i) signalling events
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PGF and NRP1 |
placental growth factor |
neuropilin 1 |
- VEGF binds to VEGFR leading to receptor dimerization
- VEGF ligand-receptor interactions
- Signaling by VEGF
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- Signal transduction by L1
- CHL1 interactions
- Axon guidance
- Semaphorin interactions
- Signaling by VEGF
- Sema3A PAK dependent Axon repulsion
- Neurophilin interactions with VEGF and VEGFR
- L1CAM interactions
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
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PGK1 and DISC1 |
phosphoglycerate kinase 1 |
disrupted in schizophrenia 1 |
- Gluconeogenesis
- Glucose metabolism
- Myoclonic epilepsy of Lafora
- Glycogen storage diseases
- Glycolysis
- Metabolism of carbohydrates
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PHB and SMARCA2 |
prohibitin |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
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- Chromatin modifying enzymes
- Chromatin organization
- RMTs methylate histone arginines
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PIN1 and BAG6 |
peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
BCL2-associated athanogene 6 |
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Negative regulators of RIG-I/MDA5 signaling
- ISG15 antiviral mechanism
- Interferon Signaling
- Cytokine Signaling in Immune system
- Antiviral mechanism by IFN-stimulated genes
- Innate Immune System
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PIN1 and TCF4 |
peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
transcription factor 4 |
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Negative regulators of RIG-I/MDA5 signaling
- ISG15 antiviral mechanism
- Interferon Signaling
- Cytokine Signaling in Immune system
- Antiviral mechanism by IFN-stimulated genes
- Innate Immune System
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- CDO in myogenesis
- Myogenesis
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PITX1 and SMARCA2 |
paired-like homeodomain 1 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
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- Chromatin modifying enzymes
- Chromatin organization
- RMTs methylate histone arginines
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PLA2G1B and PLAA |
phospholipase A2, group IB (pancreas) |
phospholipase A2-activating protein |
- Acyl chain remodelling of PG
- Acyl chain remodelling of PE
- Synthesis of PA
- Metabolism of lipids and lipoproteins
- Acyl chain remodelling of PI
- Phospholipid metabolism
- Glycerophospholipid biosynthesis
- Acyl chain remodelling of PC
- Acyl chain remodelling of PS
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PLA2G2A and BAG6 |
phospholipase A2, group IIA (platelets, synovial fluid) |
BCL2-associated athanogene 6 |
- Acyl chain remodelling of PG
- Acyl chain remodelling of PE
- Synthesis of PA
- Metabolism of lipids and lipoproteins
- Acyl chain remodelling of PI
- Phospholipid metabolism
- Glycerophospholipid biosynthesis
- Acyl chain remodelling of PC
- Acyl chain remodelling of PS
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- Indomethacin
- Diclofenac
- Ginkgo biloba
- 1,4-Butanediol
- 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene
- N-Tridecanoic Acid
- [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid
- 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid
- 1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid
- 6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid
- Elaidoylamide
- 1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide
- (S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid
- Suramin
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PLCB3 and PARD3 |
phospholipase C, beta 3 (phosphatidylinositol-specific) |
par-3 family cell polarity regulator |
- G alpha (q) signalling events
- Signaling by GPCR
- Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
- Integration of energy metabolism
- G beta:gamma signalling through PLC beta
- Signaling by Wnt
- Synthesis of IP3 and IP4 in the cytosol
- Gastrin-CREB signalling pathway via PKC and MAPK
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- PLC beta mediated events
- G-protein beta:gamma signalling
- Opioid Signalling
- Regulation of insulin secretion
- G-protein mediated events
- Activation of Kainate Receptors upon glutamate binding
- Inositol phosphate metabolism
- beta-catenin independent WNT signaling
- Presynaptic function of Kainate receptors
- G alpha (q) signalling events
- GPCR downstream signaling
- Acetylcholine regulates insulin secretion
- Ca2+ pathway
- Free fatty acids regulate insulin secretion
- Transmission across Chemical Synapses
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- Loss of Function of TGFBR2 in Cancer
- Cell junction organization
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Tight junction interactions
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Cell-cell junction organization
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
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PLK1 and BAG6 |
polo-like kinase 1 |
BCL2-associated athanogene 6 |
- Phosphorylation of the APC/C
- Mitotic Prometaphase
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Organelle biogenesis and maintenance
- Mitotic Telophase/Cytokinesis
- Separation of Sister Chromatids
- Mitotic Prophase
- Golgi Cisternae Pericentriolar Stack Reorganization
- Activation of NIMA Kinases NEK9, NEK6, NEK7
- Nuclear Envelope Breakdown
- G2/M Transition
- Mitotic Metaphase/Anaphase Transition
- Phosphorylation of Emi1
- Mitotic Anaphase
- Regulation of PLK1 Activity at G2/M Transition
- M Phase
- Cyclin A/B1 associated events during G2/M transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Assembly of the primary cilium
- Regulation of APC/C activators between G1/S and early anaphase
- Anchoring of the basal body to the plasma membrane
- APC/C-mediated degradation of cell cycle proteins
- Cell Cycle, Mitotic
- Loss of proteins required for interphase microtubule organization from the centrosome
- Resolution of Sister Chromatid Cohesion
- Regulation of mitotic cell cycle
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Centrosome maturation
- Condensation of Prophase Chromosomes
- Mitotic G2-G2/M phases
- Polo-like kinase mediated events
- Mitotic Metaphase and Anaphase
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PLXNA1 and NRP1 |
plexin A1 |
neuropilin 1 |
- Axon guidance
- Semaphorin interactions
- Other semaphorin interactions
- Sema3A PAK dependent Axon repulsion
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
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- Signal transduction by L1
- CHL1 interactions
- Axon guidance
- Semaphorin interactions
- Signaling by VEGF
- Sema3A PAK dependent Axon repulsion
- Neurophilin interactions with VEGF and VEGFR
- L1CAM interactions
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
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DCAF6 and TRIM63 |
DDB1 and CUL4 associated factor 6 |
tripartite motif containing 63, E3 ubiquitin protein ligase |
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- Antigen processing: Ubiquitination & Proteasome degradation
- Class I MHC mediated antigen processing & presentation
- Adaptive Immune System
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DCAF6 and TRIM55 |
DDB1 and CUL4 associated factor 6 |
tripartite motif containing 55 |
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POLR2A and PHF8 |
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa |
PHD finger protein 8 |
- RNA Polymerase II Promoter Escape
- mRNA Splicing
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- PIWI-interacting RNA (piRNA) biogenesis
- Nucleotide Excision Repair
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase II Transcription
- Abortive elongation of HIV-1 transcript in the absence of Tat
- HIV Infection
- Regulatory RNA pathways
- Formation of the Early Elongation Complex
- Tat-mediated elongation of the HIV-1 transcript
- Tat-mediated HIV elongation arrest and recovery
- Formation of transcription-coupled NER (TC-NER) repair complex
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- Dual incision reaction in TC-NER
- Influenza Life Cycle
- HIV elongation arrest and recovery
- HIV Life Cycle
- HIV Transcription Initiation
- Influenza Viral RNA Transcription and Replication
- RNA Pol II CTD phosphorylation and interaction with CE
- Transcriptional regulation of pluripotent stem cells
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Transcriptional regulation by small RNAs
- Processing of Capped Intron-Containing Pre-mRNA
- mRNA Capping
- mRNA Splicing - Minor Pathway
- mRNA Splicing - Major Pathway
- MicroRNA (miRNA) biogenesis
- Influenza Infection
- Pausing and recovery of Tat-mediated HIV elongation
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- Pausing and recovery of HIV elongation
- Formation of HIV elongation complex in the absence of HIV Tat
- Transcription-coupled NER (TC-NER)
- Viral Messenger RNA Synthesis
- Formation of the HIV-1 Early Elongation Complex
- RNA Polymerase II Transcription Initiation
- Transcription of the HIV genome
- RNA Polymerase II Transcription Elongation
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- Chromatin modifying enzymes
- Chromatin organization
- HDMs demethylate histones
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POLR2A and CTDP1 |
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa |
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 |
- RNA Polymerase II Promoter Escape
- mRNA Splicing
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- PIWI-interacting RNA (piRNA) biogenesis
- Nucleotide Excision Repair
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase II Transcription
- Abortive elongation of HIV-1 transcript in the absence of Tat
- HIV Infection
- Regulatory RNA pathways
- Formation of the Early Elongation Complex
- Tat-mediated elongation of the HIV-1 transcript
- Tat-mediated HIV elongation arrest and recovery
- Formation of transcription-coupled NER (TC-NER) repair complex
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- Dual incision reaction in TC-NER
- Influenza Life Cycle
- HIV elongation arrest and recovery
- HIV Life Cycle
- HIV Transcription Initiation
- Influenza Viral RNA Transcription and Replication
- RNA Pol II CTD phosphorylation and interaction with CE
- Transcriptional regulation of pluripotent stem cells
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Transcriptional regulation by small RNAs
- Processing of Capped Intron-Containing Pre-mRNA
- mRNA Capping
- mRNA Splicing - Minor Pathway
- mRNA Splicing - Major Pathway
- MicroRNA (miRNA) biogenesis
- Influenza Infection
- Pausing and recovery of Tat-mediated HIV elongation
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- Pausing and recovery of HIV elongation
- Formation of HIV elongation complex in the absence of HIV Tat
- Transcription-coupled NER (TC-NER)
- Viral Messenger RNA Synthesis
- Formation of the HIV-1 Early Elongation Complex
- RNA Polymerase II Transcription Initiation
- Transcription of the HIV genome
- RNA Polymerase II Transcription Elongation
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- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription
- Abortive elongation of HIV-1 transcript in the absence of Tat
- HIV Infection
- Formation of the Early Elongation Complex
- Tat-mediated elongation of the HIV-1 transcript
- Tat-mediated HIV elongation arrest and recovery
- RNA Polymerase II Pre-transcription Events
- Late Phase of HIV Life Cycle
- Pausing and recovery of Tat-mediated HIV elongation
- Formation of RNA Pol II elongation complex
- HIV elongation arrest and recovery
- HIV Life Cycle
- Pausing and recovery of HIV elongation
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- HIV Transcription Elongation
- Transcription of the HIV genome
- RNA Polymerase II Transcription Elongation
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POLR2B and CTDP1 |
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa |
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 |
- RNA Polymerase II Promoter Escape
- mRNA Splicing
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- PIWI-interacting RNA (piRNA) biogenesis
- Nucleotide Excision Repair
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase II Transcription
- Abortive elongation of HIV-1 transcript in the absence of Tat
- HIV Infection
- Regulatory RNA pathways
- Formation of the Early Elongation Complex
- Tat-mediated elongation of the HIV-1 transcript
- Tat-mediated HIV elongation arrest and recovery
- Formation of transcription-coupled NER (TC-NER) repair complex
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- Dual incision reaction in TC-NER
- Influenza Life Cycle
- HIV elongation arrest and recovery
- HIV Life Cycle
- HIV Transcription Initiation
- Influenza Viral RNA Transcription and Replication
- RNA Pol II CTD phosphorylation and interaction with CE
- Transcriptional regulation of pluripotent stem cells
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Transcriptional regulation by small RNAs
- Processing of Capped Intron-Containing Pre-mRNA
- mRNA Capping
- mRNA Splicing - Minor Pathway
- mRNA Splicing - Major Pathway
- MicroRNA (miRNA) biogenesis
- Influenza Infection
- Pausing and recovery of Tat-mediated HIV elongation
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- Pausing and recovery of HIV elongation
- Formation of HIV elongation complex in the absence of HIV Tat
- Transcription-coupled NER (TC-NER)
- Viral Messenger RNA Synthesis
- Formation of the HIV-1 Early Elongation Complex
- RNA Polymerase II Transcription Initiation
- Transcription of the HIV genome
- RNA Polymerase II Transcription Elongation
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- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription
- Abortive elongation of HIV-1 transcript in the absence of Tat
- HIV Infection
- Formation of the Early Elongation Complex
- Tat-mediated elongation of the HIV-1 transcript
- Tat-mediated HIV elongation arrest and recovery
- RNA Polymerase II Pre-transcription Events
- Late Phase of HIV Life Cycle
- Pausing and recovery of Tat-mediated HIV elongation
- Formation of RNA Pol II elongation complex
- HIV elongation arrest and recovery
- HIV Life Cycle
- Pausing and recovery of HIV elongation
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- HIV Transcription Elongation
- Transcription of the HIV genome
- RNA Polymerase II Transcription Elongation
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POLR2J and BAG6 |
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa |
BCL2-associated athanogene 6 |
- RNA Polymerase II Promoter Escape
- mRNA Splicing
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- PIWI-interacting RNA (piRNA) biogenesis
- Nucleotide Excision Repair
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase II Transcription
- Abortive elongation of HIV-1 transcript in the absence of Tat
- HIV Infection
- Regulatory RNA pathways
- Formation of the Early Elongation Complex
- Tat-mediated elongation of the HIV-1 transcript
- Tat-mediated HIV elongation arrest and recovery
- Formation of transcription-coupled NER (TC-NER) repair complex
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- Dual incision reaction in TC-NER
- Influenza Life Cycle
- HIV elongation arrest and recovery
- HIV Life Cycle
- HIV Transcription Initiation
- Influenza Viral RNA Transcription and Replication
- RNA Pol II CTD phosphorylation and interaction with CE
- Transcriptional regulation of pluripotent stem cells
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Transcriptional regulation by small RNAs
- Processing of Capped Intron-Containing Pre-mRNA
- mRNA Capping
- mRNA Splicing - Minor Pathway
- mRNA Splicing - Major Pathway
- MicroRNA (miRNA) biogenesis
- Influenza Infection
- Pausing and recovery of Tat-mediated HIV elongation
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- Pausing and recovery of HIV elongation
- Formation of HIV elongation complex in the absence of HIV Tat
- Transcription-coupled NER (TC-NER)
- Viral Messenger RNA Synthesis
- Formation of the HIV-1 Early Elongation Complex
- RNA Polymerase II Transcription Initiation
- Transcription of the HIV genome
- RNA Polymerase II Transcription Elongation
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POU3F2 and PQBP1 |
POU class 3 homeobox 2 |
polyglutamine binding protein 1 |
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POU3F2 and SOX10 |
POU class 3 homeobox 2 |
SRY (sex determining region Y)-box 10 |
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