Schizophrenia - Wiki-Pi

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide
MYC and SMARCA2	v-myc avian myelocytomatosis viral oncogene homolog	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Loss of Function of TGFBR2 in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt Cyclin E associated events during G1/S transition binding of TCF/LEF:CTNNB1 to target gene promoters TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation G1/S Transition Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Mitotic G1-G1/S phases FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer S Phase Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex TCF dependent signaling in response to WNT Signaling by NOTCH1 PEST Domain Mutants in Cancer Cyclin A:Cdk2-associated events at S phase entry Signaling by WNT in cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
MYO1A and DISC1	myosin IA	disrupted in schizophrenia 1
MYO5B and TCF4	myosin VB	transcription factor 4	Vasopressin regulates renal water homeostasis via Aquaporins Aquaporin-mediated transport	CDO in myogenesis Myogenesis
MYOD1 and TCF4	myogenic differentiation 1	transcription factor 4	CDO in myogenesis Myogenesis	CDO in myogenesis Myogenesis
MYOD1 and RORA	myogenic differentiation 1	RAR-related orphan receptor A	CDO in myogenesis Myogenesis	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Nuclear Receptor transcription pathway Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
HNRNPM and PRRC2A	heterogeneous nuclear ribonucleoprotein M	proline-rich coiled-coil 2A	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
NARS and LSM1	asparaginyl-tRNA synthetase	LSM1, U6 small nuclear RNA associated	Cytosolic tRNA aminoacylation tRNA Aminoacylation	mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay	L-Asparagine
NBL1 and BAG6	neuroblastoma 1, DAN family BMP antagonist	BCL2-associated athanogene 6
NCK1 and TNIK	NCK adaptor protein 1	TRAF2 and NCK interacting kinase	Signaling by PDGF Signaling by the B Cell Receptor (BCR) Generation of second messenger molecules Axon guidance DCC mediated attractive signaling VEGFA-VEGFR2 Pathway TCR signaling Activation of Rac Signaling by VEGF Downstream signal transduction Nephrin interactions Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System	Oxidative Stress Induced Senescence Cellular Senescence
NCK1 and MAP4K4	NCK adaptor protein 1	mitogen-activated protein kinase kinase kinase kinase 4	Signaling by PDGF Signaling by the B Cell Receptor (BCR) Generation of second messenger molecules Axon guidance DCC mediated attractive signaling VEGFA-VEGFR2 Pathway TCR signaling Activation of Rac Signaling by VEGF Downstream signal transduction Nephrin interactions Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System	Oxidative Stress Induced Senescence Cellular Senescence
NDUFA6 and BAG6	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa	BCL2-associated athanogene 6	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport		NADH
NDUFB9 and FEZ1	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa	fasciculation and elongation protein zeta 1 (zygin I)	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport		NADH
NEDD4 and TNIK	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	TRAF2 and NCK interacting kinase	Downregulation of ERBB4 signaling Antigen processing: Ubiquitination & Proteasome degradation ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Adaptive Immune System	Oxidative Stress Induced Senescence Cellular Senescence
NEFM and TNIK	neurofilament, medium polypeptide	TRAF2 and NCK interacting kinase		Oxidative Stress Induced Senescence Cellular Senescence
NEFM and DISC1	neurofilament, medium polypeptide	disrupted in schizophrenia 1
NEK1 and FEZ1	NIMA-related kinase 1	fasciculation and elongation protein zeta 1 (zygin I)
NEK2 and MAD1L1	NIMA-related kinase 2	MAD1 mitotic arrest deficient-like 1 (yeast)	Organelle biogenesis and maintenance APC/C:Cdc20 mediated degradation of mitotic proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes	Mitotic Spindle Checkpoint Amplification of signal from the kinetochores Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cell Cycle Checkpoints Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
NEUROD1 and TCF4	neuronal differentiation 1	transcription factor 4	Regulation of beta-cell development Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Regulation of gene expression in beta cells	CDO in myogenesis Myogenesis
NEUROG1 and TCF4	neurogenin 1	transcription factor 4		CDO in myogenesis Myogenesis
NFKB1 and SP1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Sp1 transcription factor	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB Transcriptional regulation of white adipocyte differentiation MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Regulated proteolysis of p75NTR Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Interleukin-1 processing Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Metabolism of lipids and lipoproteins Cellular Senescence SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer Oncogene Induced Senescence SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) SMAD4 MH2 Domain Mutants in Cancer	Thalidomide Pranlukast Triflusal

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