KCNJ2 and AKAP5 |
potassium channel, inwardly rectifying subfamily J, member 2 |
A kinase (PRKA) anchor protein 5 |
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Integration of energy metabolism
- Regulation of insulin secretion
- Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
- Trafficking of AMPA receptors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Transmission across Chemical Synapses
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KCNJ2 and KCNJ16 |
potassium channel, inwardly rectifying subfamily J, member 2 |
potassium channel, inwardly rectifying subfamily J, member 16 |
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Potassium transport channels
- Activation of G protein gated Potassium channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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KCNJ2 and KCNJ4 |
potassium channel, inwardly rectifying subfamily J, member 2 |
potassium channel, inwardly rectifying subfamily J, member 4 |
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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KCNJ2 and KCNJ8 |
potassium channel, inwardly rectifying subfamily J, member 2 |
potassium channel, inwardly rectifying subfamily J, member 8 |
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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- Inwardly rectifying K+ channels
- ATP sensitive Potassium channels
- Potassium Channels
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KCNJ2 and KCNJ11 |
potassium channel, inwardly rectifying subfamily J, member 2 |
potassium channel, inwardly rectifying subfamily J, member 11 |
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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- Inwardly rectifying K+ channels
- Integration of energy metabolism
- ATP sensitive Potassium channels
- Regulation of insulin secretion
- Potassium Channels
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- Glimepiride
- Ibutilide
- Verapamil
- Levosimendan
- Glyburide
- Diazoxide
- Thiamylal
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KCNJ2 and TRAK2 |
potassium channel, inwardly rectifying subfamily J, member 2 |
trafficking protein, kinesin binding 2 |
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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KCNJ2 and CASK |
potassium channel, inwardly rectifying subfamily J, member 2 |
calcium/calmodulin-dependent serine protein kinase (MAGUK family) |
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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- Syndecan interactions
- Nephrin interactions
- Non-integrin membrane-ECM interactions
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KCNJ2 and INADL |
potassium channel, inwardly rectifying subfamily J, member 2 |
InaD-like (Drosophila) |
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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- Cell junction organization
- Cell-cell junction organization
- Tight junction interactions
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KDR and NRP1 |
kinase insert domain receptor |
neuropilin 1 |
- VEGF binds to VEGFR leading to receptor dimerization
- EPHA-mediated growth cone collapse
- VEGF ligand-receptor interactions
- Axon guidance
- VEGFR2 mediated cell proliferation
- Signaling by VEGF
- EPH-Ephrin signaling
- Neurophilin interactions with VEGF and VEGFR
- Integrin cell surface interactions
- VEGFA-VEGFR2 Pathway
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- Signal transduction by L1
- CHL1 interactions
- Axon guidance
- Semaphorin interactions
- Signaling by VEGF
- Sema3A PAK dependent Axon repulsion
- Neurophilin interactions with VEGF and VEGFR
- L1CAM interactions
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
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- Sorafenib
- Sunitinib
- N-(4-{4-AMINO-6-[4-(METHYLOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-5-YL}PHENYL)-N\'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA
- Pazopanib
- Axitinib
- 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
- N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
- N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide
- 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide
- N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE
- N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE
- 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one
- 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one
- N\'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide
- N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
- N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
- Cabozantinib
- Regorafenib
- Ponatinib
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KIF3C and DISC1 |
kinesin family member 3C |
disrupted in schizophrenia 1 |
- Organelle biogenesis and maintenance
- MHC class II antigen presentation
- Kinesins
- Assembly of the primary cilium
- Factors involved in megakaryocyte development and platelet production
- Intraflagellar transport
- Adaptive Immune System
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KIF5A and KIF5C |
kinesin family member 5A |
kinesin family member 5C |
- Peptide hormone metabolism
- MHC class II antigen presentation
- Kinesins
- Insulin processing
- Factors involved in megakaryocyte development and platelet production
- Adaptive Immune System
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- Peptide hormone metabolism
- Insulin processing
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KIF5A and MAP4K4 |
kinesin family member 5A |
mitogen-activated protein kinase kinase kinase kinase 4 |
- Peptide hormone metabolism
- MHC class II antigen presentation
- Kinesins
- Insulin processing
- Factors involved in megakaryocyte development and platelet production
- Adaptive Immune System
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- Oxidative Stress Induced Senescence
- Cellular Senescence
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KIF5C and NCOA2 |
kinesin family member 5C |
nuclear receptor coactivator 2 |
- Peptide hormone metabolism
- Insulin processing
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- PPARA activates gene expression
- Bile acid and bile salt metabolism
- Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
- Organelle biogenesis and maintenance
- Metabolism of lipids and lipoproteins
- Metabolic disorders of biological oxidation enzymes
- Phase 1 - Functionalization of compounds
- Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
- RORA activates circadian gene expression
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
- Generic Transcription Pathway
- Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
- Cytochrome P450 - arranged by substrate type
- Endogenous sterols
- Transcriptional regulation of white adipocyte differentiation
- Biological oxidations
- Synthesis of bile acids and bile salts
- Orphan transporters
- Defective FMO3 causes Trimethylaminuria (TMAU)
- Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
- Fatty acid, triacylglycerol, and ketone body metabolism
- Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
- Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
- Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
- Recycling of bile acids and salts
- Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
- REV-ERBA represses gene expression
- Defective CYP1B1 causes Glaucoma
- Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
- Mitochondrial biogenesis
- Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
- Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
- Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
- Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
- Synthesis of bile acids and bile salts via 27-hydroxycholesterol
- Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
- Defective MAOA causes Brunner syndrome (BRUNS)
- Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Activation of gene expression by SREBF (SREBP)
- Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- Transcriptional activation of mitochondrial biogenesis
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
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KIF5C and SNAPIN |
kinesin family member 5C |
SNAP-associated protein |
- Peptide hormone metabolism
- Insulin processing
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- Golgi Associated Vesicle Biogenesis
- trans-Golgi Network Vesicle Budding
- Clathrin derived vesicle budding
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KIF5C and YWHAG |
kinesin family member 5C |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma |
- Peptide hormone metabolism
- Insulin processing
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- Organelle biogenesis and maintenance
- Translocation of GLUT4 to the plasma membrane
- Activation of BH3-only proteins
- Assembly of the primary cilium
- G2/M Transition
- Regulation of PLK1 Activity at G2/M Transition
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- Activation of BAD and translocation to mitochondria
- Loss of proteins required for interphase microtubule organization from the centrosome
- Loss of Nlp from mitotic centrosomes
- Programmed Cell Death
- Centrosome maturation
- Mitotic G2-G2/M phases
- Recruitment of mitotic centrosome proteins and complexes
- Intrinsic Pathway for Apoptosis
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KIF5C and KLC1 |
kinesin family member 5C |
kinesin light chain 1 |
- Peptide hormone metabolism
- Insulin processing
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- MHC class II antigen presentation
- Kinesins
- Factors involved in megakaryocyte development and platelet production
- Adaptive Immune System
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KIF5C and KLC3 |
kinesin family member 5C |
kinesin light chain 3 |
- Peptide hormone metabolism
- Insulin processing
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- MHC class II antigen presentation
- Kinesins
- Factors involved in megakaryocyte development and platelet production
- Adaptive Immune System
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KISS1 and MMP16 |
KiSS-1 metastasis-suppressor |
matrix metallopeptidase 16 (membrane-inserted) |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- G alpha (q) signalling events
- G alpha (q) signalling events
- Signaling by GPCR
- GPCR downstream signaling
- Peptide ligand-binding receptors
- Gastrin-CREB signalling pathway via PKC and MAPK
- Class A/1 (Rhodopsin-like receptors)
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
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- Activation of Matrix Metalloproteinases
- Degradation of the extracellular matrix
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KIT and PTPRU |
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
protein tyrosine phosphatase, receptor type, U |
- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- PIP3 activates AKT signaling
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of KIT signaling
- PI3K/AKT activation
- PI-3K cascade
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Innate Immune System
- Signaling by PDGF
- Signalling by NGF
- DAP12 interactions
- GAB1 signalosome
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by ERBB4
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by FGFR
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
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- Sorafenib
- Imatinib
- Dasatinib
- Sunitinib
- Phosphonotyrosine
- Adenosine-5\'-Diphosphate
- Nilotinib
- Pazopanib
- Regorafenib
- Ponatinib
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KPNA3 and NFKB1 |
karyopherin alpha 3 (importin alpha 4) |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
- ISG15 antiviral mechanism
- Interferon Signaling
- Cytokine Signaling in Immune system
- Antiviral mechanism by IFN-stimulated genes
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- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Thalidomide
- Pranlukast
- Triflusal
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