KCNJ2 and KCNJ16

Number of citations of the paper that reports this interaction (PMID 11240146)
12

Data Source:
HPRD (in vitro)

		KCNJ2	KCNJ16
Gene Name		potassium channel, inwardly rectifying subfamily J, member 2	potassium channel, inwardly rectifying subfamily J, member 16
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Intercalated Disc T-tubule Intrinsic Component Of Membrane Neuronal Cell Body Dendritic Spine	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization	Inward Rectifier Potassium Channel Activity
	Biological Process	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Magnesium Ion Transport Cellular Potassium Ion Homeostasis Protein Homotetramerization Relaxation Of Cardiac Muscle Regulation Of Resting Membrane Potential Regulation Of Membrane Repolarization Cellular Response To Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Relaxation Of Skeletal Muscle Positive Regulation Of Potassium Ion Transmembrane Transport	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Ion Transmembrane Transport
Pathways		GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses	GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Potassium transport channels Activation of G protein gated Potassium channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Cardiac repolarization ( 22342860) Formal thought disorder in schizophrenia ( 22648509) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulmonary function (interaction) ( 23284291) QT interval ( 19305409) Refractive error ( 23396134) Thyrotoxic hypokalemic periodic paralysis ( 22863731 22399142)	Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Thyrotoxic hypokalemic periodic paralysis ( 22863731)
Protein-Protein Interactions		14 interactors: AKAP5 CASK DLG1 DLG2 DLG3 DLG4 FLNA IL16 INADL KCNJ11 KCNJ16 KCNJ4 KCNJ8 TRAK2	3 interactors: KCNJ10 KCNJ15 KCNJ2
Entrez ID		3759	3773
HPRD ID		02815	16146
Ensembl ID		ENSG00000123700	ENSG00000153822
Uniprot IDs		P63252	A8K434 K7EJR9 Q9NPI9
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Synaptic Transmission Receptor Clustering Nucleotide Phosphorylation Protein Localization To Synapse Cell-cell Signaling Potassium Ion Import Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Membrane Potassium Ion Transmembrane Transport Cellular Protein Localization Potassium Ion Transport Nucleotide Metabolic Process Signaling Nucleobase-containing Small Molecule Metabolic Process Cell Communication Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Cellular Process Metal Ion Transport Membrane Organization Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Small Molecule Metabolic Process Cellular Localization Positive Regulation Of Ion Transport Cell Junction Assembly Organophosphate Metabolic Process Chemotaxis Tight Junction Assembly Cation Transport Monovalent Inorganic Cation Transport Regulation Of Membrane Potential Regulation Of Establishment Of Protein Localization Transport Negative Regulation Of Phosphatase Activity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Negative Regulation Of Dephosphorylation Apical Junction Assembly Regulation Of Protein Localization Positive Regulation Of Ion Transmembrane Transport Cell Projection Morphogenesis Cell Part Morphogenesis Protein Stabilization Axon Guidance Negative Regulation Of Transport	Potassium Ion Import Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Transport Potassium Ion Homeostasis Regulation Of Ion Transmembrane Transport Synaptic Transmission Regulation Of Ion Transport Monovalent Inorganic Cation Transport Protein Homotetramerization Metal Ion Transport Protein Tetramerization Cell-cell Signaling Cation Transmembrane Transport Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Cation Transport Ion Transmembrane Transport Relaxation Of Skeletal Muscle L-glutamate Uptake Involved In Synaptic Transmission Protein Homooligomerization Response To Blue Light Regulation Of Membrane Potential Transmembrane Transport Ion Transport Protein Oligomerization Cellular Potassium Ion Homeostasis L-glutamate Import Regulation Of Skeletal Muscle Contraction Metal Ion Homeostasis Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Neurotransmitter Uptake Membrane Repolarization Relaxation Of Cardiac Muscle Ion Homeostasis Optic Nerve Development Amino Acid Import Positive Regulation Of Potassium Ion Transmembrane Transport Central Nervous System Myelination Relaxation Of Muscle Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Magnesium Ion Transport Regulation Of Sensory Perception Of Pain L-glutamate Transport Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Chemical Homeostasis Regulation Of Long-term Neuronal Synaptic Plasticity
Tagcloud ?		alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus
Tagcloud (Difference) ?		alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus
Tagcloud (Intersection) ?