SRGAP3 and DTNBP1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		SRGAP3	DTNBP1
Gene Name		SLIT-ROBO Rho GTPase activating protein 3	dystrobrevin binding protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Endosome Membrane Postsynaptic Density Sarcoplasm Cell Junction Axon Growth Cone Synaptic Vesicle Membrane BLOC-1 Complex Melanosome Membrane Sarcolemma Neuron Projection Dendritic Spine Postsynaptic Membrane
	Molecular Function	Protein Binding Rac GTPase Activator Activity Rac GTPase Binding	Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Migration Positive Regulation Of Rac GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Positive Regulation Of Neurotransmitter Secretion Post-Golgi Vesicle-mediated Transport Blood Coagulation Anterograde Axon Cargo Transport Positive Regulation Of Gene Expression Regulation Of Dopamine Secretion Neuron Projection Development Actin Cytoskeleton Reorganization Melanosome Organization Anterograde Synaptic Vesicle Transport Neuron Projection Morphogenesis Platelet Dense Granule Organization Regulation Of Dopamine Receptor Signaling Pathway Membrane Organization
Pathways		Inactivation of Cdc42 and Rac Rho GTPase cycle Axon guidance Signaling by Rho GTPases Signaling by Robo receptor	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: DISC1 DTNBP1 FASLG KDM1A PRMT6 SMARCC2 SUV39H1 TNIK WASF1	53 interactors: ABI3 AKAP6 ARFIP2 BLOC1S5 BLOC1S6 BRF1 BRK1 C19orf66 CCDC146 CCDC153 CCDC53 CCHCR1 CCNA2 CCND3 CMYA5 DCTN1 DGCR6L DST DTNA DTNB ELOVL7 EXOC4 EXOC7 GLTSCR1L HAUS1 IFT20 IPO5 KALRN KANSL1 KIAA0408 KIFC3 MACF1 NBEA NDN NUF2 P4HA3 PSME3 RAB11A RBSN SDCBP SFR1 SNAPIN SRGAP3 SSC5D SYBU SYNE1 TRAF3IP1 TRIM2 TRIM27 TRIM32 TRIM9 TXLNB ZNF490
Entrez ID		9901	84062
HPRD ID		12108	06190
Ensembl ID		ENSG00000196220	ENSG00000047579
Uniprot IDs		O43295	D6RJC6 Q96EV8
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cell Differentiation Chromatin Modification Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neural Precursor Cell Proliferation Actin Cytoskeleton Reorganization Positive Regulation Of Stem Cell Proliferation Histone Modification Chromosome Organization Regulation Of Primitive Erythrocyte Differentiation Endomembrane System Organization Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Forebrain Development Cytoskeleton Organization Regulation Of Metabolic Process Regulation Of Neural Precursor Cell Proliferation Nervous System Development Histone H3-R2 Methylation Transcription, DNA-templated Developmental Process Regulation Of Stem Cell Proliferation RNA Biosynthetic Process Histone Methylation Endosomal Lumen Acidification Actin Cytoskeleton Organization Response To Stimulus Positive Regulation Of Cellular Metabolic Process Actin Filament-based Process Retinal Cell Programmed Cell Death System Development Generation Of Neurons Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Involved In Forebrain Neuron Fate Commitment Protein Methylation Regulation Of Cellular Process Necroptotic Signaling Pathway Neurogenesis Brain Development Histone H3-K9 Dimethylation Regulation Of Dopamine Receptor Signaling Pathway Head Development Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation	Establishment Of Localization In Cell Movement Of Cell Or Subcellular Component Cellular Pigmentation Cellular Localization Endosomal Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Organelle Organization Intracellular Transport Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Organelle Localization Microtubule-based Process Vesicle-mediated Transport Microtubule-based Movement Establishment Of Vesicle Localization Establishment Of Organelle Localization Pigmentation Vesicle Localization Protein Localization Protein Transport Anterograde Synaptic Vesicle Transport Establishment Of Protein Localization Melanosome Organization Pigment Granule Organization Anterograde Axon Cargo Transport Exocytosis Secretion By Cell Cell Projection Organization Synaptic Vesicle Transport Positive Regulation Of Cell Growth Endosome To Melanosome Transport Pigment Granule Maturation Axon Cargo Transport Small GTPase Mediated Signal Transduction Secretion Synaptic Vesicle Exocytosis Cellular Pigment Accumulation Nervous System Development Regulation Of Calcineurin-NFAT Signaling Cascade Cytoplasmic Transport Transport Positive Regulation Of Pigment Cell Differentiation Mitotic Nuclear Division Neuron Development Positive Regulation Of Developmental Pigmentation Negative Regulation Of Viral Release From Host Cell Generation Of Neurons
Tagcloud ?		3p anomalies arm camk1 congenital creld1 define deleted deletion deletions features give handicap interstitial involve kb lengths mb mtmr14 overlap presents prove respect rise seizures syndrome tada3 terminus typical	additive alleles cc convergent correction dysbindin glutamatergic heterozygotes homozygotes india irrespective morphometry neuregulin noted nrg1 pathophysiological polymorphism polymorphisms preliminary reductions rs1011313 rs35753505 schizophrenia tc trend uncorrected viz volumetric voxel
Tagcloud (Difference) ?		3p anomalies arm camk1 congenital creld1 define deleted deletion deletions features give handicap interstitial involve kb lengths mb mtmr14 overlap presents prove respect rise seizures syndrome tada3 terminus typical	additive alleles cc convergent correction dysbindin glutamatergic heterozygotes homozygotes india irrespective morphometry neuregulin noted nrg1 pathophysiological polymorphism polymorphisms preliminary reductions rs1011313 rs35753505 schizophrenia tc trend uncorrected viz volumetric voxel
Tagcloud (Intersection) ?