GAB2 and LAT

Number of citations of the paper that reports this interaction (PMID 11572860)
16

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GAB2	LAT
Gene Name		GRB2-associated binding protein 2	linker for activation of T cells
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Immunological Synapse Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Cell Migration Osteoclast Differentiation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Mast Cell Degranulation Innate Immune Response Phosphatidylinositol-mediated Signaling	Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		Signaling by GPCR Signaling by FGFR in disease G-protein beta:gamma signalling Cytokine Signaling in Immune system Role of LAT2/NTAL/LAB on calcium mobilization Signaling by SCF-KIT Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Signaling by FGFR1 mutants Interleukin receptor SHC signaling Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants GPVI-mediated activation cascade Interleukin-2 signaling Signaling by FGFR1 fusion mutants Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Innate Immune System	TCR signaling Generation of second messenger molecules GPVI-mediated activation cascade Platelet activation, signaling and aggregation Adaptive Immune System
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 17553421) Menarche (age at onset) ( 21102462)	Crohn's disease ( 21102463)
Protein-Protein Interactions		28 interactors: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SRC SYK TNFRSF11A ZAP70	28 interactors: CBL CD244 CD4 CD8A FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK LCK LCP2 MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2
Entrez ID		9846	27040
HPRD ID		05866	03832
Ensembl ID		ENSG00000033327	ENSG00000213658
Uniprot IDs		Q9UQC2	B7WPI0 G5E9K3 O43561
PDB IDs		2VWF 2W0Z
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Innate Immune Response Fc-epsilon Receptor Signaling Pathway Immune Response Positive Regulation Of Signal Transduction Blood Coagulation Intracellular Signal Transduction Regulation Of Immune System Process Hemostasis Positive Regulation Of Immune System Process Platelet Activation Positive Regulation Of Immune Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of T Cell Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Immune System Process Leukocyte Migration Defense Response T Cell Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Cell-cell Adhesion Wound Healing Regulation Of Cell Activation T Cell Costimulation Regulation Of Cell-cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Response To Wounding Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Signal Transduction Positive Regulation Of Cell Adhesion Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Activation	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune Response Innate Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune Response Defense Response Positive Regulation Of Cell Activation Blood Coagulation Hemostasis Immune System Process Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Signal Transduction Signaling Cell Communication Platelet Activation Regulation Of Body Fluid Levels Response To Stress Wound Healing Positive Regulation Of T Cell Activation Regulation Of Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Activation Leukocyte Activation T Cell Costimulation Leukocyte Migration Positive Regulation Of Cell-cell Adhesion Response To Wounding Positive Regulation Of Cell Adhesion Phagocytosis Lymphocyte Activation Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of T Cell Activation Leukocyte Differentiation
Tagcloud ?		adaptor adenocarcinomas compensate contribution deletion demonstrating driven egfr egfrl858r erbb2 erbb3 gab1 inducible initiate inositol member met mutant observations phosphatidyl pi3k plasticity remarkable retained tamoxifen tetracycline tkis tumorigenesis	abolish acting amp beginning besides box contributed cre deleting element elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution tata true unexplored usf
Tagcloud (Difference) ?		adaptor adenocarcinomas compensate contribution deletion demonstrating driven egfr egfrl858r erbb2 erbb3 gab1 inducible initiate inositol member met mutant observations phosphatidyl pi3k plasticity remarkable retained tamoxifen tetracycline tkis tumorigenesis	abolish acting amp beginning besides box contributed cre deleting element elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution tata true unexplored usf
Tagcloud (Intersection) ?