GPRASP1 and CHRM4

Number of citations of the paper that reports this interaction (PMID 15452121)
38

Data Source:
HPRD (in vitro)

		GPRASP1	CHRM4
Gene Name		G protein-coupled receptor associated sorting protein 1	cholinergic receptor, muscarinic 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Postsynaptic Membrane
	Molecular Function	Protein Binding	G-protein Coupled Acetylcholine Receptor Activity
	Biological Process	Endosome To Lysosome Transport G-protein Coupled Receptor Catabolic Process	Signal Transduction Cell Surface Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Acetylcholine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Cell Proliferation Regulation Of Locomotion
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Ziprasidone Amitriptyline Olanzapine Metixene Clozapine Trihexyphenidyl Procyclidine Promazine Hyoscyamine Imipramine Darifenacin Nortriptyline Atropine Nicardipine Paroxetine Homatropine Methylbromide Scopolamine Benzquinamide Propiomazine Cryptenamine Tropicamide Brompheniramine Maprotiline Tolterodine Promethazine Doxepin Desipramine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Solifenacin Isopropamide Fesoterodine Aclidinium
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1	3 interactors: EEF1A2 GPRASP1 GRB2
Entrez ID		9737	1132
HPRD ID		02333	00330
Ensembl ID		ENSG00000198932	ENSG00000180720
Uniprot IDs		Q5JY77	P08173
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Cytosolic Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Response To Stimulus Cellular Metal Ion Homeostasis Cell-cell Signaling Positive Regulation Of Smooth Muscle Contraction Cellular Cation Homeostasis Cellular Ion Homeostasis Signaling Signal Transduction Metal Ion Homeostasis Cell Communication Blood Circulation Cellular Chemical Homeostasis Ion Homeostasis Response To Stimulus Neuropeptide Signaling Pathway Regulation Of Muscle Contraction G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cellular Homeostasis Chemical Homeostasis Regulation Of Blood Pressure Tachykinin Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Opioid Receptor Signaling Pathway Regulation Of Vasoconstriction Positive Regulation Of Uterine Smooth Muscle Contraction Neurological System Process Homeostatic Process Regulation Of Cellular Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Blood Pressure Behavior Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Regulation Of Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of CAMP Metabolic Process Response To Abiotic Stimulus Regulation Of Adenylate Cyclase Activity	Receptor Metabolic Process G-protein Coupled Receptor Catabolic Process
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