ZNF646 and NINL

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		ZNF646	NINL
Gene Name		zinc finger protein 646	ninein-like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Microtubule Organizing Center Cytosol Microtubule
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding	Calcium Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization
Pathways			Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: C11orf30 MDFI NINL PRKG1 TRAF2 UBE2I	45 interactors: AKAP17A APEX2 CCDC130 CCDC146 CCDC33 CCHCR1 CLEC1B DCTN5 EWSR1 EZH2 FAM107A FAM161A GCC1 GPKOW HAUS1 JUNB KANSL1 KAT5 KAT7 L3MBTL4 LRSAM1 LZTS2 MAD1L1 MBIP MCM10 PLK1 RBM41 RCOR3 RGS2 RIBC2 SH2D4A SH3BP5L SPERT SYT17 TCEANC TCEB3 TNNT1 TSPYL4 UTP14A ZFC3H1 ZFHX3 ZNF250 ZNF417 ZNF426 ZNF646
Entrez ID		9726	22981
HPRD ID		15886	11120
Ensembl ID		ENSG00000167395	ENSG00000101004
Uniprot IDs		O15015	Q9Y2I6
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of SUMO Transferase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Regulation Of Catalytic Activity Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Binding Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Relaxation Of Vascular Smooth Muscle Positive Regulation Of Protein Homodimerization Activity CGMP-mediated Signaling Relaxation Of Smooth Muscle Positive Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Platelet Aggregation Cellular Response To Nitric Oxide Regulation Of Immunoglobulin Secretion Response To Nitric Oxide Regulation Of Cell-cell Adhesion Organelle Organization Negative Regulation Of Smooth Muscle Contraction Regulation Of Platelet Aggregation Trophoblast Giant Cell Differentiation Negative Regulation Of Platelet Activation Cellular Response To Stress Positive Regulation Of Catalytic Activity Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Regulation Of Protein Homodimerization Activity Positive Regulation Of MAPK Cascade Response To Stress Cellular Response To Reactive Nitrogen Species Positive Regulation Of Protein Kinase Activity Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Negative Regulation Of Muscle Contraction Regulation Of Cell Activation Relaxation Of Muscle Positive Regulation Of Kinase Activity Cytoplasmic Sequestering Of Protein	RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Gene Expression Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Peptidyl-lysine Modification Protein Acetylation Cellular Nitrogen Compound Metabolic Process Chromatin Organization Protein Localization To Chromatin Chromosome Organization Cell Cycle Histone H4-K5 Acetylation Histone H4-K8 Acetylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Modification Histone Modification Regulation Of Transcription, DNA-templated Negative Regulation Of Muscle Contraction Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Organelle Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Protein Localization To Chromosome Cell Cycle Process Mitotic Spindle Checkpoint Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Chromosome Segregation Mitotic Nuclear Division Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Ubiquitin-dependent Endocytosis Regulation Of Metaphase Plate Congression Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Muscle Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process
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