NOS1AP and SYN1

Number of citations of the paper that reports this interaction (PMID 11867766)
19

Data Source:
HPRD (in vivo)

		NOS1AP	SYN1
Gene Name		nitric oxide synthase 1 (neuronal) adaptor protein	synapsin I
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Caveola Z Disc T-tubule Nuclear Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Perinuclear Region Of Cytoplasm Inward Rectifier Potassium Channel Complex L-type Voltage-gated Calcium Channel Complex	Golgi Apparatus Cytosol Synaptic Vesicle Cell Junction Dendrite
	Molecular Function	Nitric-oxide Synthase Binding	Actin Binding Catalytic Activity Transporter Activity Protein Binding ATP Binding Protein Kinase Binding Calcium-dependent Protein Binding
	Biological Process	Regulation Of Heart Rate By Chemical Signal Positive Regulation Of Gene Expression Positive Regulation Of Nitric Oxide Mediated Signal Transduction Regulation Of Apoptotic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Generation Of L-type Calcium Current Positive Regulation Of Peptidyl-cysteine S-nitrosylation	Synaptic Transmission Neurotransmitter Secretion Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Vesicle Exocytosis
Pathways			Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Electrocardiographic traits ( 20062061 20062063) Obesity-related traits ( 23251661) QT interval ( 23166209 20031603 16648850 22726844 19305408 19305409 19587794) Word reading ( 23738518)
Protein-Protein Interactions		11 interactors: APP FAM133A LRP1 LRP2 LRP8 NOS1 RASD1 SYN1 SYN2 SYN3 TRAF4	30 interactors: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 S100A1 SH3GL2 SNCA SPTAN1 SRC SYN2 SYN3 VIM
Entrez ID		9722	6853
HPRD ID		12023	02433
Ensembl ID		ENSG00000198929	ENSG00000008056
Uniprot IDs		O75052	P17600
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Neurotransmitter Levels Signaling Cell Communication Phototransduction, Visible Light Retinoid Metabolic Process Regulation Of Synaptic Transmission Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Response To Light Stimulus Neurotransmitter Secretion Detection Of Light Stimulus Isoprenoid Metabolic Process Nitric Oxide Mediated Signal Transduction Response To Radiation Neurotransmitter Transport Secretion By Cell Response To Abiotic Stimulus Detection Of Abiotic Stimulus Regulation Of Signaling Secretion Endocytosis Steroid Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Alcohol Metabolic Process Receptor-mediated Endocytosis Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Ammon Gyrus Development Beta-amyloid Clearance Regulation Of Cellular Amino Acid Metabolic Process Blood Coagulation Hemostasis Forebrain Development Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Synaptic Growth At Neuromuscular Junction Regulation Of Cellular Ketone Metabolic Process Cholesterol Metabolic Process Transport Positive Regulation Of Protein Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Negative Regulation Of Serotonin Uptake Sterol Metabolic Process Lipid Metabolic Process Detection Of Stimulus Regulation Of Body Fluid Levels Second-messenger-mediated Signaling	Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Endocytosis Positive Regulation Of Metabolic Process Regulation Of Cellular Component Organization Axon Guidance Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Chemotaxis Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Axonogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Regulation Of Protein Kinase Activity Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Axon Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Locomotion Cell Differentiation Positive Regulation Of Cellular Metabolic Process Signaling Regulation Of Protein Phosphorylation Neuron Projection Morphogenesis Regulation Of Signaling Nervous System Development Neurotrophin TRK Receptor Signaling Pathway Cell Communication Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Neurotrophin Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization T Cell Costimulation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Actin Filament-based Process Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?		accomplices counterbalance dao daoa dictate dpysl2 dtnbp1 famine grin1 grin2b grm3 grm4 hypomyelination il1b il1rn impa2 metabotropic ncam1 nd4 ndufv2 nurture oligodendrocyte pdlim5 pik3c3 pip5k2a reconcile rgs4 ywhah	anthropometry bf bifidobacterium bifidogenic breastfed breastfeeding carbohydrates closer colonized digestive faecal fermentable formula formulas infant inulin microbiota nct00808756 newborns oligofructose orafti prebiotic softer sterile stool stools supplemented synergy1 try
Tagcloud (Difference) ?		accomplices counterbalance dao daoa dictate dpysl2 dtnbp1 famine grin1 grin2b grm3 grm4 hypomyelination il1b il1rn impa2 metabotropic ncam1 nd4 ndufv2 nurture oligodendrocyte pdlim5 pik3c3 pip5k2a reconcile rgs4 ywhah	anthropometry bf bifidobacterium bifidogenic breastfed breastfeeding carbohydrates closer colonized digestive faecal fermentable formula formulas infant inulin microbiota nct00808756 newborns oligofructose orafti prebiotic softer sterile stool stools supplemented synergy1 try
Tagcloud (Intersection) ?