SH3PXD2A and ADAM15

Number of citations of the paper that reports this interaction (PMID 16374509)
26

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro)

		SH3PXD2A	ADAM15
Gene Name		SH3 and PX domains 2A	ADAM metallopeptidase domain 15
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Podosome Cytoplasm Cell Junction Cell Projection	Acrosomal Vesicle Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Cell Projection Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding
	Biological Process	Superoxide Metabolic Process	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Protein Kinase C Signaling Negative Regulation Of Receptor Binding
Pathways			Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		6 interactors: ADAM15 FASLG KHDRBS1 PAK2 SRC SVIL	32 interactors: ABL1 ARHGEF6 ARHGEF7 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1
Entrez ID		9644	8751
HPRD ID		10228	05674
Ensembl ID		ENSG00000107957	ENSG00000143537
Uniprot IDs		B3KPL1 F5GZ35 Q5TCZ1	B4DMH8 Q13444 U3KQL5
PDB IDs		2DNU 2EGA 2EGC 2EKH
Enriched GO Terms of Interacting Partners?		Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell-substrate Adhesion Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Immune Response T Cell Costimulation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Peptidyl-serine Phosphorylation Regulation Of Cell-matrix Adhesion Integrin-mediated Signaling Pathway Regulation Of Proteolysis Cell Development Positive Regulation Of RNA Export From Nucleus Cellular Response To Progesterone Stimulus Cell Morphogenesis Involved In Differentiation Regulation Of Protein Binding Regulation Of Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Endosomal Lumen Acidification Negative Regulation Of Cellular Metabolic Process System Development Immune System Process Regulation Of Protein Metabolic Process Retinal Cell Programmed Cell Death Regulation Of Cell-substrate Adhesion Regulation Of Cell Cycle Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Protein Autophosphorylation Positive Regulation Of Integrin Activation Positive Regulation Of Podosome Assembly Negative Regulation Of Mitochondrial Depolarization Cell-substrate Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Apoptotic Process	Peptidyl-tyrosine Autophosphorylation Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Costimulation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Axon Guidance Phagocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Membrane Tubulation Regulation Of Endocytosis Regulation Of Cell Adhesion Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Cellular Response To Peptide Positive Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Axonogenesis Positive Regulation Of Cell Adhesion Regulation Of Vesicle-mediated Transport Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Locomotion Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Axon Development Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		6beta analyzing bands bisphosphate cleft confers crest diverges essentiality exon exons homozygous hypothesize intron invadosome isoform lacked lacks leaving mefs named palate scaffold start tags tks5 tks5beta triplet	adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Difference) ?		6beta analyzing bands bisphosphate cleft confers crest diverges essentiality exon exons homozygous hypothesize intron invadosome isoform lacked lacks leaving mefs named palate scaffold start tags tks5 tks5beta triplet	adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Intersection) ?