CD40 and HSPA4

Number of citations of the paper that reports this interaction (PMID 12356871)
55

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo)

		CD40	HSPA4
Gene Name		CD40 molecule, TNF receptor superfamily member 5	heat shock 70kDa protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface CD40 Receptor Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Mitochondrion Cytosol Extracellular Vesicular Exosome
	Molecular Function	Antigen Binding Signal Transducer Activity Receptor Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding	ATP Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Complex Assembly Cellular Calcium Ion Homeostasis Inflammatory Response Platelet Activation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-12 Production Positive Regulation Of Rac GTPase Activity B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Regulation Of Immunoglobulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Apoptotic Process	Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Chaperone-mediated Protein Complex Assembly
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Kawasaki disease ( 22446961 22446962) Multiple sclerosis ( 22190364 19525955 21833088) Rheumatoid arthritis ( 18794853 20453842)
Protein-Protein Interactions		26 interactors: BIRC2 BIRC3 CAV1 CBL CD40LG FAF1 HSPA4 HSPA8 IL4R JAK3 MAP3K8 MS4A1 NCOA6 NSMAF PIK3R1 RIPK2 SUMO1 TDP2 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 XRCC5 XRCC6	58 interactors: AGTRAP APPBP2 BAG1 BAG2 BAG5 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB1 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPBP1 IKBKG KPNA2 KRT18 MAPT NFKB1 NR3C2 OLR1 PHLDA1 PPP1CA PRKCB PRKCD PRKCG PRSS23 PSMD10 RAF1 REL RELA SMAD3 SOD1 ST13 STIP1 STUB1 SUGT1 TERT TIMM44 TOMM40 TRAF6 TTC1 UBE2L3 UBE3A
Entrez ID		958	3308
HPRD ID		00178	09025
Ensembl ID		ENSG00000101017
Uniprot IDs		P25942	P34932
PDB IDs		1CDF 1CZZ 1D00 1FLL 1LB6 3QD6
Enriched GO Terms of Interacting Partners?		Immune System Process Immune Response Regulation Of Apoptotic Process Apoptotic Process Regulation Of Cell Death Programmed Cell Death Cell Death Death Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell-cell Adhesion Regulation Of Immune System Process Defense Response Toll-like Receptor 4 Signaling Pathway Innate Immune Response Response To Stress Regulation Of T Cell Activation Regulation Of Immune Response Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Toll-like Receptor Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Pattern Recognition Receptor Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Cell Adhesion Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Cell Communication Regulation Of Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction	Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Cell Death Death Neurotrophin Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Negative Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Growth Factor Stimulus Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Response To Growth Factor Cellular Response To Stimulus Programmed Cell Death Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Negative Regulation Of Signal Transduction Cellular Metabolic Process Signaling Response To Stimulus Cell Communication Regulation Of Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Cell Death Cellular Protein Metabolic Process Signal Transduction Regulation Of Protein Phosphorylation Immune System Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death
Tagcloud ?		adhesion affinity bind cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction	competence cumulus damaged domestic fertility hfs2 hsf hsf1 hsp110 hsp40 hsp90a hsp90b hsph1 hsps machinery oocyte oocytes operational ovaries ovary pig preserve sows summer unexpectedly warm winter
Tagcloud (Difference) ?		adhesion affinity bind cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction	competence cumulus damaged domestic fertility hfs2 hsf hsf1 hsp110 hsp40 hsp90a hsp90b hsph1 hsps machinery oocyte oocytes operational ovaries ovary pig preserve sows summer unexpectedly warm winter
Tagcloud (Intersection) ?