PMPCB and PMPCA

Number of citations of the paper that reports this interaction (PMID 10942759)
9

Data Source:
HPRD (in vitro)

		PMPCB	PMPCA
Gene Name		peptidase (mitochondrial processing) beta	peptidase (mitochondrial processing) alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Matrix	Extracellular Space Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Metalloendopeptidase Activity Metal Ion Binding	Metalloendopeptidase Activity Metal Ion Binding
	Biological Process	Proteolysis Protein Targeting To Mitochondrion Cellular Protein Metabolic Process	Proteolysis Protein Targeting To Mitochondrion Cellular Protein Metabolic Process
Pathways		Mitochondrial protein import	Mitochondrial protein import
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		3 interactors: FXN MARK3 PMPCA	3 interactors: BMPR2 PMPCB SKIV2L
Entrez ID		9512	23203
HPRD ID		07539	07500
Ensembl ID		ENSG00000105819	ENSG00000165688
Uniprot IDs		B3KM34 E7ERZ4 O75439 Q96CP5	Q10713
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Ferrochelatase Activity Iron Incorporation Into Metallo-sulfur Cluster Proprioception Mitochondrion Organization Positive Regulation Of Metalloenzyme Activity Protein Autoprocessing Neuromuscular Process Controlling Posture Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Multicellular Organism Growth Iron-sulfur Cluster Assembly Heme Biosynthetic Process Negative Regulation Of Mitochondrion Organization Response To Iron Ion Porphyrin-containing Compound Biosynthetic Process Negative Regulation Of Organ Growth Positive Regulation Of Oxidoreductase Activity Heme Metabolic Process Positive Regulation Of Lyase Activity Adult Walking Behavior Cellular Protein Metabolic Process Porphyrin-containing Compound Metabolic Process Pigment Biosynthetic Process Cellular Response To Hydrogen Peroxide Aerobic Respiration Protein Targeting To Mitochondrion Oxidative Phosphorylation Protein Localization To Mitochondrion Regulation Of Oxidoreductase Activity	Regulation Of Lung Blood Pressure Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Vasoconstriction Positive Regulation Of Axon Extension Involved In Axon Guidance Lymphatic Endothelial Cell Differentiation Lymphangiogenesis Lymph Vessel Morphogenesis Regulation Of Axon Extension Involved In Axon Guidance Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Lymph Vessel Development Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of DNA Biosynthetic Process
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