NRXN1 and SYT1

Number of citations of the paper that reports this interaction (PMID 11243866)
14

Data Source:
HPRD (in vitro)

		NRXN1	SYT1
Gene Name		neurexin 1	synaptotagmin I
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Endocytic Vesicle Presynaptic Membrane Axonal Growth Cone	Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Dense Core Granule SNARE Complex Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	Receptor Activity Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Metal Ion Binding Calcium-dependent Protein Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	SNARE Binding Phosphatidylserine Binding Transporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Phospholipid Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding Syntaxin-1 Binding Clathrin Binding Identical Protein Binding Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Angiogenesis Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebellar Granule Cell Differentiation Neuronal Signal Transduction Extracellular Matrix Organization Adult Behavior Social Behavior Protein Localization To Synapse Vocal Learning Establishment Of Protein Localization Neuromuscular Process Controlling Balance Negative Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vocalization Behavior Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Protein Complex Assembly Involved In Synapse Maturation Positive Regulation Of Synapse Maturation Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gamma-aminobutyric Acid Receptor Clustering N-methyl-D-aspartate Receptor Clustering Gephyrin Clustering Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior	Detection Of Calcium Ion Synaptic Transmission Neurotransmitter Secretion Pathogenesis Glutamate Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Positive Regulation Of Synaptic Transmission Protein Homooligomerization Regulation Of Synaptic Transmission, Glutamatergic Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway
Pathways		Non-integrin membrane-ECM interactions	Dopamine Neurotransmitter Release Cycle Toxicity of botulinum toxin type G (BoNT/G) Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Longevity ( 20834067) Metabolite levels (HVA/MHPG ratio) ( 23319000) Personality dimensions ( 20691247) Temperament ( 22832960)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		28 interactors: APBA1 APBA2 ATP13A2 CASK MACF1 MLLT4 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3	30 interactors: CACNA1A CACNB3 CACNB4 CALM1 FGF1 GNB2L1 GOLM1 IKBKG IRF3 NEDD4 NR1H3 NR3C1 NRXN1 PPARG RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A ZDHHC17
Entrez ID		9378	6857
HPRD ID		11858	01710
Ensembl ID		ENSG00000179915	ENSG00000067715
Uniprot IDs		A4FVB9 A7E294 P58400 Q49A31 Q9ULB1	J3KQA0 P21579
PDB IDs		3B3Q	2K45 2K4A 2K8M 2KI6 2LHA 2R83 3F00 3F01 3F04 3F05 4ISQ
Enriched GO Terms of Interacting Partners?		Secretion Exocytosis Secretion By Cell Transport Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Calcium Ion-dependent Exocytosis Cell-cell Signaling Regulation Of Respiratory Gaseous Exchange By Neurological System Process Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Exocytosis Regulation Of Exocytosis Regulation Of Synaptic Transmission, Glutamatergic Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Synaptic Transmission Membrane Biogenesis Terminal Button Organization Postsynaptic Membrane Organization Regulation Of Secretion Positive Regulation Of Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Transport Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Regulation Of Dendritic Spine Development Positive Regulation Of Secretion Regulation Of Synapse Assembly Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Postsynaptic Density Protein 95 Clustering Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Protein Localization Regulation Of Postsynaptic Membrane Potential Synapse Assembly Protein Transport Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Synaptic Transmission, GABAergic Establishment Of Protein Localization Regulation Of Synapse Organization Protein Localization	Cell-cell Signaling Neurotransmitter Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Transmission Vesicle Localization Regulation Of Cellular Localization Exocytosis Regulation Of Signaling Organelle Localization Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Signaling Establishment Of Vesicle Localization Regulation Of Cellular Component Organization Cell Communication Establishment Of Localization In Cell Intracellular Receptor Signaling Pathway Cellular Localization Establishment Of Organelle Localization Vesicle Fusion Vesicle-mediated Transport Membrane Depolarization Membrane Fusion Acid Secretion Regulation Of Vesicle-mediated Transport Protein Localization Regulation Of Protein Localization Regulation Of Membrane Potential Organelle Fusion Regulation Of Secretion Glucocorticoid Receptor Signaling Pathway Regulation Of Immune Response Vesicle Docking Transport Regulation Of Synaptic Transmission Establishment Of Protein Localization Membrane Docking Regulation Of Signal Transduction Positive Regulation Of Synaptic Transmission Calcium Ion-dependent Exocytosis Regulation Of Protein Secretion Regulation Of Cellular Process Cell Differentiation Protein Transport Regulation Of Protein Localization To Plasma Membrane Membrane Organization
Tagcloud ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes
Tagcloud (Difference) ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes
Tagcloud (Intersection) ?