NOLC1 and USP4

Number of citations of the paper that reports this interaction (PMID 11571651)
5

Data Source:
HPRD (in vivo)

		NOLC1	USP4
Gene Name		nucleolar and coiled-body phosphoprotein 1	ubiquitin specific peptidase 4 (proto-oncogene)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cajal Body	Nucleus Cytoplasm Lysosome Plasma Membrane
	Molecular Function	Protein Binding ATP Binding GTP Binding Poly(A) RNA Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding
	Biological Process	RRNA Processing Nucleolus Organization Cell Cycle Mitotic Nuclear Division	Spliceosomal Tri-snRNP Complex Assembly Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		13 interactors: APP CEBPB COIL CSNK2A1 CSNK2B E2F4 ERG GTF2B POLR1A PRKACA USP4 YWHAG YWHAQ	46 interactors: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A FAM96B HUWE1 IGKV2D-29 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBL1 RBL2 RCC1 SART3 SMN1 TCF4 TGFBR1 TK1 TP53BP2 TRAF2 TRAF6 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28
Entrez ID		9221	7375
HPRD ID		03864	04598
Ensembl ID		ENSG00000166197	ENSG00000114316
Uniprot IDs		Q14978	Q08AK7 Q13107
PDB IDs			2Y6E
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Gene Expression Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process RNA Metabolic Process Nervous System Development Negative Regulation Of Protein Metabolic Process Cell Differentiation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Multicellular Organismal Development Apoptotic Process Regulation Of Gene Expression Programmed Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Death Intrinsic Apoptotic Signaling Pathway Death Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Chemotaxis DNA-templated Transcription, Initiation Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of Intracellular Transport System Development Positive Regulation Of Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Cardiac Conduction Regulation Of Proteolysis Regulation Of Binding Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Phase Transition Protein Phosphorylation Cell Cycle Positive Regulation Of Transport Regulation Of Protein Kinase Activity Positive Regulation Of Mitochondrion Organization Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Negative Regulation Of Catalytic Activity Regulation Of Apoptotic Process Regulation Of Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Potassium Ion Export RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Apoptotic Process Cell Cycle Response To Stress Programmed Cell Death Cell Death Death Response To Stimulus Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Protein Ubiquitination Mitotic Cell Cycle Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Immune System Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Proteolysis Regulation Of Lipid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Transferase Activity Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Catalytic Activity Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Intracellular Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle Checkpoint Cellular Response To Stimulus Mitotic G1 DNA Damage Checkpoint Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?			1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers
Tagcloud (Difference) ?			1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers
Tagcloud (Intersection) ?