VAPB and MTNR1A

Number of citations of the paper that reports this interaction (PMID 17215244)
14

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		VAPB	MTNR1A
Gene Name		VAMP (vesicle-associated membrane protein)-associated protein B and C	melatonin receptor 1A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Membrane Endoplasmic Reticulum Exit Site	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Protein Heterodimerization Activity Beta-tubulin Binding	Protein Binding Melatonin Receptor Activity Hormone Binding Organic Cyclic Compound Binding
	Biological Process	Sphingolipid Metabolic Process Cellular Calcium Ion Homeostasis ER To Golgi Vesicle-mediated Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Organization Modulation By Virus Of Host Morphology Or Physiology Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Small Molecule Metabolic Process Negative Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Negative Regulation By Virus Of Viral Protein Levels In Host Cell COPII-coated Vesicle Budding	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Mating Behavior Circadian Rhythm Positive Regulation Of CGMP Biosynthetic Process
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Ramelteon Melatonin Agomelatine
Diseases
GWAS			Obesity ( 21552555)
Protein-Protein Interactions		15 interactors: FAF1 GPR25 MTNR1A OSBPL2 RMDN2 STX1A STX2 STX4 STX5 USP20 VAMP1 VAMP2 VAPA VHL VKORC1	26 interactors: CALR CANX CNP DPM1 EEF1G FLNA GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 LRRC59 MTNR1B PDIA6 PGRMC1 RAB10 RAC1 RAP1A TMEM33 VAPB
Entrez ID		9217	4543
HPRD ID		09300	02812
Ensembl ID		ENSG00000124164	ENSG00000168412
Uniprot IDs		O95292 Q53XM7	P48039
PDB IDs		3IKK
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Membrane Fusion Organelle Fusion Vesicle Organization Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Vesicle Exocytosis Vesicle Docking Membrane Docking Membrane Organization Vesicle-mediated Transport Neurotransmitter Secretion Synaptic Vesicle Transport Exocytosis Regulation Of Neurotransmitter Levels Calcium Ion-dependent Exocytosis Neurotransmitter Transport Cellular Protein Localization Establishment Of Vesicle Localization Vesicle Localization Secretion By Cell Golgi Vesicle Transport SNARE Complex Assembly Cellular Localization Secretion Establishment Of Organelle Localization Positive Regulation Of Synaptic Transmission Protein Localization Establishment Of Localization In Cell Organelle Localization Response To Hydroperoxide Glutamate Secretion Regulation Of Exocytosis Intracellular Protein Transport Intracellular Transport Regulation Of Insulin Secretion Pathogenesis Regulation Of Peptide Hormone Secretion Synaptic Transmission Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Transport Long-term Synaptic Potentiation Regulation Of Hormone Secretion Regulation Of Establishment Of Protein Localization Transport Acid Secretion Positive Regulation Of Exocytosis Regulation Of Synaptic Transmission Protein Transport Regulation Of Protein Localization Organelle Organization	Platelet Activation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Signaling Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Signal Transduction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Organic Substance Positive Regulation Of Nuclease Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Kinase Activity Vesicle-mediated Transport Positive Regulation Of Transferase Activity Response To Stress Synaptic Transmission Cell-cell Signaling Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Stimulus Cellular Response To Topologically Incorrect Protein Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Dopamine Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Organic Substance Response To Unfolded Protein Regulation Of Kinase Activity Membrane Organization Positive Regulation Of Phosphorylation Response To Endoplasmic Reticulum Stress Cell Surface Receptor Signaling Pathway Neural Nucleus Development Positive Regulation Of Protein Modification Process Ras Protein Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Response To Peptide Hormone Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		2alpha bip centrally chaperone chlamydia chlamydiae chlamydial cpn eif2alpha endoplasmic er eukaryotic exogenous gamma grp78 ifn inclusions inducer interacted interplay maintain persistent pneumoniae productive restore reticulum unfolded upr vesicle
Tagcloud (Difference) ?		2alpha bip centrally chaperone chlamydia chlamydiae chlamydial cpn eif2alpha endoplasmic er eukaryotic exogenous gamma grp78 ifn inclusions inducer interacted interplay maintain persistent pneumoniae productive restore reticulum unfolded upr vesicle
Tagcloud (Intersection) ?