MAP3K13 and GLO1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MAP3K13	GLO1
Gene Name		mitogen-activated protein kinase kinase kinase 13	glyoxalase I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	IkappaB Kinase Complex Membrane	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Lactoylglutathione Lyase Activity Zinc Ion Binding
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity	Carbohydrate Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Glutathione Metabolic Process Methylglyoxal Metabolic Process Osteoclast Differentiation Negative Regulation Of Apoptotic Process
Pathways
Drugs			Glutathione Indomethacin S-P-Nitrobenzyloxycarbonylglutathione S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione Beta-Mercaptoethanol S-Benzyl-Glutathione S-Hexylglutathione methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
Diseases
GWAS		Airflow obstruction ( 22837378)
Protein-Protein Interactions		7 interactors: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3	3 interactors: IKBKG MAP3K13 MEOX2
Entrez ID		9175	2739
HPRD ID		05372	00730
Ensembl ID		ENSG00000073803	ENSG00000124767
Uniprot IDs		O43283	Q04760
PDB IDs			1BH5 1FRO 1QIN 1QIP 3VW9
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Response To Cytokine Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Organic Substance Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of JUN Kinase Activity JNK Cascade Defense Response Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Peptidyl-cysteine Oxidation Response To Tumor Necrosis Factor Positive Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Antigen Receptor-mediated Signaling Pathway Activation Of Innate Immune Response Regulation Of JNK Cascade Phosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Sorbitol Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Stress-activated MAPK Cascade Intracellular Receptor Signaling Pathway Regulation Of Immune Response	JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MAPK Cascade Activation Of Protein Kinase Activity Signal Transduction By Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Somite Specification Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Regulation Of MAPK Cascade Segment Specification Positive Regulation Of Protein Phosphorylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Kinase Activity Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Modification Process B Cell Homeostasis NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 5 Signaling Pathway Regulation Of RNA Metabolic Process Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?			accelerate aggravate aggravating asp carboxy coactivators damages detoxifies epo erythropoiesis erythropoietin esa glu glycation glycative glyoxalse hif hypoxia impedes indoxyl master messenger posttranscriptional suppresses toxins transactivator tubules uremia uremic
Tagcloud (Difference) ?			accelerate aggravate aggravating asp carboxy coactivators damages detoxifies epo erythropoiesis erythropoietin esa glu glycation glycative glyoxalse hif hypoxia impedes indoxyl master messenger posttranscriptional suppresses toxins transactivator tubules uremia uremic
Tagcloud (Intersection) ?