DYRK1B and MAP2K3

Number of citations of the paper that reports this interaction (PMID 11980910)
17

Data Source:
HPRD (in vivo)

		DYRK1B	MAP2K3
Gene Name		dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	mitogen-activated protein kinase kinase 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleoplasm Cytosol Membrane
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Receptor Signaling Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation Myoblast Fusion Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription, DNA-templated Adipose Tissue Development	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response Signal Transduction Pathogenesis Peptidyl-tyrosine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Cytokine Biosynthetic Process Innate Immune Response Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Cardiac Muscle Contraction
Pathways			MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence MyD88-independent cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: DCAF7 HDAC5 LZTS2 MAP2K3 MAPK1 MAPK14 MBP PAK1 PCBD1 RANBP9 TROAP	20 interactors: ALDOC APP ARRB1 DCTN1 DYRK1B ELK1 LRRK2 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 PLCB2 RPL13 SMAD7 TAOK1 TAOK2 TINF2
Entrez ID		9149	5606
HPRD ID		05188	03816
Ensembl ID		ENSG00000105204	ENSG00000034152
Uniprot IDs		B4DXU2 Q9Y463	P46734 Q6FI23
PDB IDs
Enriched GO Terms of Interacting Partners?		Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of MAP Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway MAPK Cascade Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Toll-like Receptor 4 Signaling Pathway Regulation Of MAP Kinase Activity Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Response To Peptide Positive Regulation Of Kinase Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Transferase Activity Cellular Response To Insulin Stimulus Chemotaxis Regulation Of MAPK Cascade Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Immune Response Immune Response Regulation Of Innate Immune Response Immune System Process Positive Regulation Of Transcription, DNA-templated Nucleocytoplasmic Transport Peptidyl-threonine Phosphorylation Nuclear Transport Multicellular Organismal Development Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Insulin Regulation Of Myotube Differentiation	MAPK Cascade Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Activation Of MAPKK Activity Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Phosphate-containing Compound Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Phosphorylation Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Activation Of Protein Kinase Activity Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Response To Stress Cellular Metabolic Process Cellular Protein Metabolic Process Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Metabolic Process Regulation Of MAP Kinase Activity Cellular Response To Stress Cellular Protein Modification Process Signaling Regulation Of JNK Cascade Cell Communication
Tagcloud ?		2a balance bm88 brdu bromo cend1 coordination cytosolic deoxyuridine destabilization elucidate exit incorporation lineage modulator neuro neuroblastoma neuronal partner pivotal precursors ran ranbpm retention reverted scaffolding stabilizes transiently	alternate ask biogenesis cascades cytochrome discovered dissociation generating glycolysis hypoxic induces mapkkk metallochaperone mitogen oxidase oxphos possess prevents redox ros sco2 switches switching thioredoxin thr tigar trx xenografts
Tagcloud (Difference) ?		2a balance bm88 brdu bromo cend1 coordination cytosolic deoxyuridine destabilization elucidate exit incorporation lineage modulator neuro neuroblastoma neuronal partner pivotal precursors ran ranbpm retention reverted scaffolding stabilizes transiently	alternate ask biogenesis cascades cytochrome discovered dissociation generating glycolysis hypoxic induces mapkkk metallochaperone mitogen oxidase oxphos possess prevents redox ros sco2 switches switching thioredoxin thr tigar trx xenografts
Tagcloud (Intersection) ?