USP10 and G3BP1

Number of citations of the paper that reports this interaction (PMID 11439350)
30

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		USP10	G3BP1
Gene Name		ubiquitin specific peptidase 10	GTPase activating protein (SH3 domain) binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule
	Molecular Function	P53 Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Ion Channel Binding Poly(A) RNA Binding	DNA Binding MRNA Binding ATP-dependent DNA Helicase Activity ATP-dependent RNA Helicase Activity Endonuclease Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	DNA Repair Autophagy Regulation Of Autophagy Protein Deubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process	Transport Ras Protein Signal Transduction Metabolic Process DNA Duplex Unwinding Negative Regulation Of Canonical Wnt Signaling Pathway Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS		Height ( 18391951)
Protein-Protein Interactions		9 interactors: AR G3BP1 G3BP2 IKBKG SCNN1A SCNN1G SNX3 TP53 UBC	11 interactors: APP CSK DTX1 EPHA8 FBXO25 HDAC6 IL7R LCK PIN1 RASA1 USP10
Entrez ID		9100	10146
HPRD ID		07029	06569
Ensembl ID		ENSG00000103194	ENSG00000145907
Uniprot IDs		Q14694	Q13283 Q5HYE9 Q5U0Q1 Q6ZP53
PDB IDs			3Q90 4FCJ 4FCM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signaling Transport Sodium Ion Homeostasis Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Ras Protein Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Stimulus Regulation Of Establishment Of Protein Localization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Localization Excretion Multicellular Organismal Water Homeostasis Regulation Of Wnt Signaling Pathway Toll-like Receptor 5 Signaling Pathway Positive Regulation Of Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Toll-like Receptor 10 Signaling Pathway Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction Involved In DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Signal Transduction Involved In Cell Cycle Checkpoint Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Programmed Cell Death Water Homeostasis TRIF-dependent Toll-like Receptor Signaling Pathway Sensory Perception Of Taste MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Death Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Localization DNA Damage Response, Signal Transduction By P53 Class Mediator	Regulation Of Cell Adhesion Cellular Protein Modification Process Regulation Of Signal Transduction Cell Communication Regulation Of T Cell Activation Neuron Remodeling Cellular Protein Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Metabolic Process Regulation Of Lymphocyte Activation Regulation Of T Cell Differentiation Cellular Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Peptidyl-amino Acid Modification Regulation Of Lymphocyte Differentiation Regulation Of Cell Activation Signal Transduction Protein Metabolic Process Regulation Of Metabolic Process Signaling Platelet Activation Neuron Maturation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of T Cell Activation Protein Autophosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Locomotion Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell-cell Adhesion Immune Response Regulation Of Proteolysis Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Regulation Of Protein Metabolic Process Cell Activation Cell Differentiation Peptidyl-tyrosine Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Activation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Tagcloud ?		bioinformatic class collectively crucial experiments function gain implicating inhibit initiation luciferase micrornas mir molecules noncoding oncogenic pancreatic play prediction pro progression promote roles stabilizing suggested suppressed targeting tumorigenesis ups10	blockade bolster capsid counters cyclophilin cypa defences disassembles displacing eef2 gag groundwork imposed infectivity lay lifts loops overexposed preformed recruiting sg sgs sh3 silent stabilizes tiar translationally triage unsuspected
Tagcloud (Difference) ?		bioinformatic class collectively crucial experiments function gain implicating inhibit initiation luciferase micrornas mir molecules noncoding oncogenic pancreatic play prediction pro progression promote roles stabilizing suggested suppressed targeting tumorigenesis ups10	blockade bolster capsid counters cyclophilin cypa defences disassembles displacing eef2 gag groundwork imposed infectivity lay lifts loops overexposed preformed recruiting sg sgs sh3 silent stabilizes tiar translationally triage unsuspected
Tagcloud (Intersection) ?