USP14 and FANCC

Number of citations of the paper that reports this interaction (PMID 14499622)
5

Data Source:
BioGRID (two hybrid)

		USP14	FANCC
Gene Name		ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	Fanconi anemia, complementation group C
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Plasma Membrane Cell Surface Cytoplasmic Membrane-bounded Vesicle Synapse Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding TRNA Guanylyltransferase Activity Proteasome Binding	Protein Binding
	Biological Process	Synaptic Transmission Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process	Myeloid Cell Homeostasis DNA Repair Nucleotide-excision Repair Protein Complex Assembly Germ Cell Development Removal Of Superoxide Radicals
Pathways			Fanconi Anemia pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: COPS5 CXCR4 FANCC UBC USP15 USP21 USP28	27 interactors: ATP6 AZIN1 CAPN10 CDK1 DNAJB1 FANCA FANCD2 FANCE FANCF FANCG GSTP1 HSP90AA1 HSP90B1 HSPA1A HSPA4 HSPA8 IK KRT1 POR RPL18 RPS3A SPTA1 SPTAN1 STAT1 TCERG1 USP14 ZBTB32
Entrez ID		9097	2176
HPRD ID		06279	01967
Ensembl ID		ENSG00000101557	ENSG00000158169
Uniprot IDs		B7Z4N8 P54578	B4E3W2 Q00597
PDB IDs		2AYN 2AYO
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Histone Deubiquitination Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Proteolysis Cellular Macromolecule Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction By P53 Class Mediator DNA Repair Regulation Of MAPK Cascade Histone H2B Conserved C-terminal Lysine Deubiquitination Activation Of MAPK Activity Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Modification Process DNA Damage Checkpoint Catabolic Process Exosomal Secretion Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Viral Life Cycle Response To Transforming Growth Factor Beta Cellular Response To DNA Damage Stimulus Positive Regulation Of MAP Kinase Activity Cell Cycle Checkpoint Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Germ Cell Development Programmed Cell Death Cullin Deneddylation Cell Death Death Activation Of Protein Kinase Activity Monoubiquitinated Protein Deubiquitination DNA Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Abiotic Stimulus	Protein Refolding Response To Unfolded Protein Cellular Response To Stress Regulation Of Cellular Response To Heat Response To Stress Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Heat DNA Repair Response To Stimulus Protein Import Into Mitochondrial Outer Membrane Response To Heat Protein Folding Response To Abiotic Stimulus Cellular Response To DNA Damage Stimulus Membrane Organization Cellular Metabolic Process Response To Organic Substance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Inclusion Body Assembly Response To Temperature Stimulus Axon Guidance Response To Oxidative Stress Response To External Stimulus Chaperone-mediated Protein Complex Assembly DNA Metabolic Process Establishment Of Protein Localization To Membrane Nucleobase-containing Compound Metabolic Process Chaperone Mediated Protein Folding Requiring Cofactor Regulation Of Apoptotic Process Cellular Response To Organonitrogen Compound Regulation Of Inclusion Body Assembly Regulation Of Cell Death Protein Localization To Organelle Female Gonad Development Axonogenesis Development Of Primary Female Sexual Characteristics Cellular Macromolecule Catabolic Process Viral Process Cellular Response To Peptide Hormone Stimulus Axon Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Cellular Response To Peptide Nitric Oxide Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Immune System Process Negative Regulation Of Programmed Cell Death Metabolic Process
Tagcloud ?		20s abstaining accumulated affecting antagonizes apigenin biochemistry bortezomib chymotrypsin depolarization desired deubiquitinase e6ap fda flavonoid mechanistically pc preferentially proteasomal proteasome psma5 psmb1 psmb2 psmb5 selectively subtle trihydroxyflavone trypsin ubiquitinated	1beta autoinhibitory bm characterizes creating cytokines fanca fanconi hypersensitive inactivated leukemic loop mapkapk mononuclear multipotent overproduced overproduction p38 phagocytes posttranscriptionally potently progenitor progenitors progressive reasoning tlr toll transcriptionally
Tagcloud (Difference) ?		20s abstaining accumulated affecting antagonizes apigenin biochemistry bortezomib chymotrypsin depolarization desired deubiquitinase e6ap fda flavonoid mechanistically pc preferentially proteasomal proteasome psma5 psmb1 psmb2 psmb5 selectively subtle trihydroxyflavone trypsin ubiquitinated	1beta autoinhibitory bm characterizes creating cytokines fanca fanconi hypersensitive inactivated leukemic loop mapkapk mononuclear multipotent overproduced overproduction p38 phagocytes posttranscriptionally potently progenitor progenitors progressive reasoning tlr toll transcriptionally
Tagcloud (Intersection) ?