ANGPTL1 and TEK

Number of citations of the paper that reports this interaction (PMID 10051567)
46

Data Source:
HPRD (in vivo, in vitro)

		ANGPTL1	TEK
Gene Name		angiopoietin-like 1	TEK tyrosine kinase, endothelial
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome	Stress Fiber Extracellular Region Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Binding	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Protein Binding ATP Binding Growth Factor Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway	Angiogenesis Response To Hypoxia Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Sprouting Angiogenesis Positive Regulation Of Cytokine Secretion Involved In Immune Response Cell-matrix Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Heart Development Blood Coagulation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Single Organismal Cell-cell Adhesion Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Organ Regeneration Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Peptidyl-serine Phosphorylation Substrate Adhesion-dependent Cell Spreading Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Response To Peptide Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Angiogenesis Protein Autophosphorylation Tie Signaling Pathway Negative Regulation Of Inflammatory Response Leukocyte Migration Protein Oligomerization Response To CAMP Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Actin Cytoskeleton Reorganization Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways			Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: NR2F6 TEK	20 interactors: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP DOK2 DOK4 GRB14 GRB2 GRB7 IKBKG PIK3R1 PTPN11 PTPRB SHC1 SOCS1 STAT5A STAT5B TIE1 TNIP2
Entrez ID		9068	7010
HPRD ID		04851	02571
Ensembl ID		ENSG00000116194	ENSG00000120156
Uniprot IDs		O95841	Q02763 Q59HG2
PDB IDs			1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V
Enriched GO Terms of Interacting Partners?		Response To Steroid Hormone Tie Signaling Pathway Positive Regulation Of Cytokine Secretion Involved In Immune Response Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Actin Cytoskeleton Reorganization Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Response To Lipid Heart Trabecula Formation Response To Organic Cyclic Compound Endothelial Cell Proliferation Response To Hormone Entrainment Of Circadian Clock By Photoperiod Definitive Hemopoiesis Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Focal Adhesion Assembly Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Adherens Junction Organization Response To Abiotic Stimulus Detection Of Temperature Stimulus Heart Trabecula Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Sensory Perception Of Temperature Stimulus Regulation Of Vascular Permeability Regulation Of Endothelial Cell Apoptotic Process Regulation Of Actin Cytoskeleton Reorganization Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of NIK/NF-kappaB Signaling Endochondral Ossification Substrate Adhesion-dependent Cell Spreading Regulation Of Focal Adhesion Assembly Trabecula Morphogenesis Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Migration Regulation Of Lipid Kinase Activity Regulation Of Cell Junction Assembly Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Development Regulation Of Cytokine Production Involved In Immune Response Organ Regeneration Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Angiogenesis Endochondral Bone Morphogenesis Regulation Of Endothelial Cell Proliferation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Body Fluid Levels Enzyme Linked Receptor Protein Signaling Pathway Leukocyte Migration Blood Coagulation Hemostasis Immune System Process Signal Transduction Wound Healing Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Wounding Cellular Response To Stimulus Cell Migration Regulation Of Immune Response Response To Stimulus Cell Motility Locomotion Response To Stress Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Growth Hormone Stimulus Cellular Response To Peptide Movement Of Cell Or Subcellular Component Positive Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of Signal Transduction Response To Growth Hormone Regulation Of Innate Immune Response Intracellular Signal Transduction Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signaling Regulation Of Kinase Activity Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Angiogenesis ERBB Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Defense Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Development Of Secondary Male Sexual Characteristics JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Tagcloud ?		achieving anovulatory blastocyst ccs competence competent cumulus embryo folliculogenesis grin2a infertility ivf lhcgr melanogenesis microarrays microenvironment oocyte ovary paracrine pcos polycystic qrt sfrp4 signatures socs3 talk tnik transendothelial u133	amplify blk bpk cdnas cmet degenerate eck f1 fer fes fgr flk fyn hck kit lacked lin ly6a ptks rtk rtks ryk sca sixteen sorted sorter stk turned tyk
Tagcloud (Difference) ?		achieving anovulatory blastocyst ccs competence competent cumulus embryo folliculogenesis grin2a infertility ivf lhcgr melanogenesis microarrays microenvironment oocyte ovary paracrine pcos polycystic qrt sfrp4 signatures socs3 talk tnik transendothelial u133	amplify blk bpk cdnas cmet degenerate eck f1 fer fes fgr flk fyn hck kit lacked lin ly6a ptks rtk rtks ryk sca sixteen sorted sorter stk turned tyk
Tagcloud (Intersection) ?