ACVR1 and CDK14

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		ACVR1	CDK14
Gene Name		activin A receptor, type I	cyclin-dependent kinase 14
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Apical Part Of Cell Activin Receptor Complex	Cytoplasmic Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Peptide Hormone Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Patterning Of Blood Vessels Urogenital System Development In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Mitral Valve Morphogenesis Atrial Septum Primum Morphogenesis Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Negative Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Tissue Development Smooth Muscle Cell Differentiation Pharyngeal System Development Pathway-restricted SMAD Protein Phosphorylation Cardiac Muscle Cell Fate Commitment Endocardial Cushion Cell Fate Commitment Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Wnt Signaling Pathway Cell Division Regulation Of Cell Cycle Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs		Adenosine triphosphate 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases
GWAS
Protein-Protein Interactions		64 interactors: AP2B1 BAMBI BMP2 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP DCAF6 DUSP13 ENG FANCL FBXO30 FCHO1 FGD6 FKBP4 FNTA GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SMAD1 SMAD5 SMAD9 SOCS6 STX8 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1 WDR61	12 interactors: ACVR1 BMPR1B CCND3 CCNY CDKN1A RB1 SEPT8 SMURF1 TGFBR1 YWHAB YWHAE YWHAQ
Entrez ID		90	5218
HPRD ID		00021	15121
Ensembl ID		ENSG00000115170	ENSG00000058091
Uniprot IDs		D3DPA4 Q04771	E7EUK8 O94921
PDB IDs		3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Signaling Cellular Response To Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Intracellular Signal Transduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Cellular Metabolic Process Response To Stimulus BMP Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Small GTPase Mediated Signal Transduction Regulation Of Cell Differentiation Regulation Of Cellular Process Ras Protein Signal Transduction Anatomical Structure Morphogenesis Positive Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Skeletal System Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cartilage Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Modification Process Response To Organic Substance Positive Regulation Of Gene Expression Epithelium Development Positive Regulation Of Cellular Biosynthetic Process SMAD Protein Signal Transduction Regulation Of Protein Metabolic Process Connective Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation	Positive Regulation Of Apoptotic Signaling Pathway Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Response To Growth Factor Regulation Of Protein Phosphorylation Positive Regulation Of Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Phosphorylation Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Localization Signaling Regulation Of Intracellular Transport Cell Communication Regulation Of Signaling Positive Regulation Of Phosphorylation Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Kinase Activity Regulation Of Cell Death Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Mitochondrion Organization Apoptotic Process Programmed Cell Death Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Positive Regulation Of Transferase Activity Cell Cycle Process Cell Death Death Positive Regulation Of Apoptotic Process BMP Signaling Pathway
Tagcloud ?		advances authors braf briefly changed counterpart decades divide extremely focus gliomas helped hggs highlight histologic historically idh lethal ntrk past pdgfra pediatric phggs rarity resection subgroups telomeres tools v600e	adenocarcinoma agent amplicon array behavior catenin cb42 cdk6 cgh chimeric colon commonly driven genomes genomic individualized invasive kras led mek metastasis metastatic near propagating propagation sequencing subcutaneous unique world
Tagcloud (Difference) ?		advances authors braf briefly changed counterpart decades divide extremely focus gliomas helped hggs highlight histologic historically idh lethal ntrk past pdgfra pediatric phggs rarity resection subgroups telomeres tools v600e	adenocarcinoma agent amplicon array behavior catenin cb42 cdk6 cgh chimeric colon commonly driven genomes genomic individualized invasive kras led mek metastasis metastatic near propagating propagation sequencing subcutaneous unique world
Tagcloud (Intersection) ?