CCNB1 and CDT1

Number of citations of the paper that reports this interaction (PMID 14993212)
48

Data Source:
BioGRID (pull down)

		CCNB1	CDT1
Gene Name		cyclin B1	chromatin licensing and DNA replication factor 1
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Gene Ontology Annotations	Cellular Component	Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Membrane	Nucleus Nucleoplasm Cytosol
	Molecular Function	Patched Binding Protein Binding Protein Kinase Binding Histone Kinase Activity	DNA Binding Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Protein Complex Assembly Mitotic Nuclear Envelope Disassembly Mitotic Metaphase Plate Congression Spermatogenesis Response To Mechanical Stimulus Negative Regulation Of Gene Expression Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone Phosphorylation Tissue Regeneration Response To Drug Mitotic Spindle Stabilization Positive Regulation Of Mitotic Cell Cycle Response To DDT Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Cell Division Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Chromosome Condensation Cellular Response To Iron(III) Ion Cellular Response To Fatty Acid Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Histone H3-S10 Phosphorylation Involved In Chromosome Condensation	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Nuclear Cell Cycle DNA Replication
Pathways		Phosphorylation of the APC/C MASTL Facilitates Mitotic Progression Mitotic Prometaphase G2/M Checkpoints Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown G2/M Transition Phosphorylation of Emi1 Recruitment of NuMA to mitotic centrosomes Regulation of PLK1 Activity at G2/M Transition M Phase Cyclin A/B1 associated events during G2/M transition G1/S Transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Mitotic G1-G1/S phases Recruitment of mitotic centrosome proteins and complexes G2/M DNA replication checkpoint Condensation of Prometaphase Chromosomes E2F mediated regulation of DNA replication G2/M DNA damage checkpoint Depolymerisation of the Nuclear Lamina Nuclear Pore Complex (NPC) Disassembly APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic APC/C:Cdc20 mediated degradation of Cyclin B Resolution of Sister Chromatid Cohesion E2F-enabled inhibition of pre-replication complex formation Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints Centrosome maturation Condensation of Prophase Chromosomes Mitotic G2-G2/M phases Polo-like kinase mediated events	E2F mediated regulation of DNA replication Synthesis of DNA Activation of the pre-replicative complex DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition Activation of the pre-replicative complex S Phase Orc1 removal from chromatin Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex Mitotic G1-G1/S phases Switching of origins to a post-replicative state
Drugs
Diseases
GWAS			mean corpuscular hemoglobin concentration ( 20139978)
Protein-Protein Interactions		54 interactors: ANAPC11 ARID4A BRCA1 CCNB1IP1 CCNF CDC20 CDC25A CDC25C CDC27 CDC6 CDK1 CDK7 CDKN1A CDKN1B CDT1 CKS2 EP300 FLNA FZR1 GADD45A GADD45B GADD45G HERC5 HIST1H1A HIST1H1B ITPR1 KAT5 MAP4 MEF2C MOK PBK PCNA PIN1 PKMYT1 PLK1 POLA1 PRC1 PSMD4 PTCH1 PTMA RAD23A RALBP1 RB1 RPA1 RUNX2 SQSTM1 TGFBR2 TP53BP1 TP73 TSC1 TSPYL2 UBE2D2 UBE3D UBQLN1	29 interactors: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DDB1 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK1 MCM4 MCM6 MCM7 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB
Entrez ID		891	81620
HPRD ID		00454	06900
Ensembl ID		ENSG00000134057	ENSG00000167513
Uniprot IDs		P14635 Q5TZP9	Q9H211
PDB IDs		2B9R 2JGZ	2LE8 2WVR
Enriched GO Terms of Interacting Partners?		Cell Cycle Process Regulation Of Cell Cycle Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Cell Cycle Checkpoint Regulation Of Kinase Activity Regulation Of Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Positive Regulation Of Protein Modification Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Cell Division Organelle Organization Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Protein Catabolic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition	Cell Cycle Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Cellular Response To Stress Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process DNA Replication Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Mitotic Cell Cycle Cellular Protein Catabolic Process Chromosome Organization Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process DNA Repair Nucleobase-containing Compound Metabolic Process Mitotic Nuclear Division Regulation Of Protein Ubiquitination G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Organelle Organization Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Negative Regulation Of Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		5q13 bacs bacterium chosen contig copy flanking hope inherited intricate legionella lgn1 map1b mapped maps muscular naip p1s pathogenicity pneumophila recessively simpler sma smas smn subcloning syntenic uncharacterized yac	assembled assembling cdc6 creates double generates head helicase heptamer hexamer hexamers hydrolysis interlocked intermediates juxtaposition license licensing loaded loaders mcm2 minichromosome misaligned multisubunit orc origins prereplication recruit replication replicative
Tagcloud (Difference) ?		5q13 bacs bacterium chosen contig copy flanking hope inherited intricate legionella lgn1 map1b mapped maps muscular naip p1s pathogenicity pneumophila recessively simpler sma smas smn subcloning syntenic uncharacterized yac	assembled assembling cdc6 creates double generates head helicase heptamer hexamer hexamers hydrolysis interlocked intermediates juxtaposition license licensing loaded loaders mcm2 minichromosome misaligned multisubunit orc origins prereplication recruit replication replicative
Tagcloud (Intersection) ?