CPNE1 and UBE2M

Number of citations of the paper that reports this interaction (PMID 12522145)
20

Data Source:
HPRD (in vitro)

		CPNE1	UBE2M
Gene Name		copine I	ubiquitin-conjugating enzyme E2M
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Vesicular Exosome	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylserine Binding Transporter Activity Calcium-dependent Phospholipid Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ribosomal S6-glutamic Acid Ligase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Lipid Metabolic Process Vesicle-mediated Transport	Cellular Protein Modification Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Ubiquitination Positive Regulation Of Neuron Apoptotic Process Protein Neddylation
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ACTB BCOR BUB3 CCDC22 CPNE4 LIG4 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SPTBN1 STK3 UBE2M UBE2O WTAP	24 interactors: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL3 CUL7 DCUN1D3 DCUN1D4 MARCH7 MDM2 NAE1 NEDD4 NEDD8 PARK2 PINK1 RBX1 RNF111 RNF7 TP53 UBA3 UBC
Entrez ID		8904	9040
HPRD ID		05014	04414
Ensembl ID		ENSG00000214078	ENSG00000130725
Uniprot IDs		B0QZ18 Q99829	P61081
PDB IDs			1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO
Enriched GO Terms of Interacting Partners?		Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Heterooligomerization Regulation Of Cellular Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Golgi To Plasma Membrane Transport Regulation Of Organelle Organization In Utero Embryonic Development Protein Monoubiquitination Generation Of Neurons Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Cycle Process Actin Filament Capping Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Neurogenesis Negative Regulation Of Histone H3-K36 Methylation DNA Ligation Involved In DNA Recombination Positive Regulation Of Cell Death Anatomical Structure Morphogenesis Negative Regulation Of Actin Filament Depolymerization Regulation Of Intracellular Signal Transduction Mitotic Cell Cycle Process Cellular Protein Metabolic Process Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Mitotic Nuclear Division Cellular Component Assembly Negative Regulation Of Tooth Mineralization Protein Metabolic Process Mitotic Cell Cycle Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Polymerization Post-Golgi Vesicle-mediated Transport Regulation Of Signal Transduction Negative Regulation Of Chromosome Organization Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Protein Complex Disassembly Axon Guidance Positive Regulation Of Cell Differentiation Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Apoptotic Process Regulation Of Protein Depolymerization	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Neddylation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Modification Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Protein Monoubiquitination Proteolysis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hypoxia Regulation Of Mitochondrion Degradation Cellular Response To Decreased Oxygen Levels Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cellular Response To Oxygen Levels Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Catabolic Process Notch Signaling Pathway Regulation Of Cell Cycle Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Cell Cycle Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Catabolic Process Viral Process Protein Polyubiquitination Negative Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Apoptotic Process Cellular Response To Toxic Substance Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process Signaling Mitotic Cell Cycle Process Response To Oxidative Stress
Tagcloud ?		affect arrangement cdnas coding connection conservation copine courses ests evolutionary exons genome genomic indicates initiated motif pairs phenomenon promoters rbm12 sequences share sharing shed splicing tags totally utr zebrafish	acts affects balance brca1 breaks choice controller controlling ctip cytotoxic deneddylation great homologous indeed neddylation nhej recombination repair repaired resection respond rnf111 ssdna strand subpathways tight toward uncover way
Tagcloud (Difference) ?		affect arrangement cdnas coding connection conservation copine courses ests evolutionary exons genome genomic indicates initiated motif pairs phenomenon promoters rbm12 sequences share sharing shed splicing tags totally utr zebrafish	acts affects balance brca1 breaks choice controller controlling ctip cytotoxic deneddylation great homologous indeed neddylation nhej recombination repair repaired resection respond rnf111 ssdna strand subpathways tight toward uncover way
Tagcloud (Intersection) ?