SYNJ1 and AP2A1

Number of citations of the paper that reports this interaction (PMID 12057195)
45

Data Source:
BioGRID (pull down)

		SYNJ1	AP2A1
Gene Name		synaptojanin 1	adaptor-related protein complex 2, alpha 1 subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Coat	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Nucleotide Binding RNA Binding Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity	Protein Binding Protein C-terminus Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Neurotransmitter Transport Synaptic Vesicle Priming Synaptic Vesicle Uncoating Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Regulation Of Synaptic Vesicle Membrane Organization Positive Regulation Of Synaptic Vesicle Uncoating	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Synthesis of IP2, IP, and Ins in the cytosol Metabolism of lipids and lipoproteins Phospholipid metabolism Inositol phosphate metabolism PI Metabolism	Trafficking of GluR2-containing AMPA receptors Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 GRB2 ITSN1 PACSIN1 PACSIN2 PACSIN3 PPP3CA SH3BP1 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SORBS2	27 interactors: AMPH AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 EHD1 EPN1 EPS15 GHR HIP1 MYO6 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1
Entrez ID		8867	160
HPRD ID		09182	03016
Ensembl ID		ENSG00000159082	ENSG00000196961
Uniprot IDs		B9EGN3 C9JFZ1 J3KPK1 J3KQV8 O43426 Q05CZ1	O95782
PDB IDs		1W80 2DNR 2VJ0
Enriched GO Terms of Interacting Partners?		Endocytosis Vesicle-mediated Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Transport Neuron Projection Morphogenesis Cell-cell Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Axonogenesis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Neuron Projection Development Regulation Of Cellular Component Organization Axon Development Cell Projection Organization Membrane Organization Synaptic Transmission Cell Morphogenesis Involved In Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Chemotaxis Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Synaptic Vesicle Transport Locomotion Neuron Development Membrane Tubulation Cell Morphogenesis Involved In Differentiation Nervous System Development Cellular Localization Movement Of Cell Or Subcellular Component Neuron Differentiation Establishment Of Localization In Cell Generation Of Neurons Regulation Of Endocytosis Neurogenesis Regulation Of Vesicle-mediated Transport Establishment Of Vesicle Localization Vesicle Localization	Vesicle-mediated Transport Endocytosis Clathrin Coat Assembly Establishment Of Localization In Cell Synaptic Vesicle Transport Cellular Localization Regulation Of Vesicle-mediated Transport Membrane Budding Transport Cellular Protein Complex Assembly Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Synaptic Transmission Signaling Membrane Organization Cell Communication Cellular Macromolecular Complex Assembly Cell-cell Signaling Establishment Of Organelle Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Regulation Of Endocytosis Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Organelle Localization Neuron Development Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Protein Complex Assembly Positive Regulation Of Transport Secretion By Cell Cellular Component Assembly Receptor Internalization Neuron Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Negative Regulation Of ERBB Signaling Pathway Generation Of Neurons Exocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Priming ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurogenesis Secretion Neuron Projection Morphogenesis Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Tagcloud ?		aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj2 targetable xenografts
Tagcloud (Difference) ?		aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj2 targetable xenografts
Tagcloud (Intersection) ?