CREG1 and CAPN1

Number of citations of the paper that reports this interaction (PMID 12358155)
3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CREG1	CAPN1
Gene Name		cellular repressor of E1A-stimulated genes 1	calpain 1, (mu/I) large subunit
Image
Gene Ontology Annotations	Cellular Component	Transcription Factor Complex Extracellular Vesicular Exosome	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome
	Molecular Function	Transcription Corepressor Activity Transcription Factor Binding FMN Binding Oxidoreductase Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Cell Proliferation Regulation Of Growth Oxidation-reduction Process Negative Regulation Of Nucleic Acid-templated Transcription	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization Receptor Catabolic Process
Pathways			Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CAPN1 IGF2R RB1 RBL1 RBL2 TBP	50 interactors: ACTC1 ACTN2 AES ARF6 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TP53 UFSP2 VIM
Entrez ID		8804	823
HPRD ID		09897	00253
Ensembl ID		ENSG00000143162	ENSG00000014216
Uniprot IDs		O75629	B2RDI5 B4DWH5 P07384
PDB IDs		1XHN	1ZCM 2ARY
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Kinase Activity Regulation Of Lipid Metabolic Process Viral Process Chromatin Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Chromatin Organization Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Centromere Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Regulation Of Cell Cycle Transcription, DNA-templated Attachment Of Mitotic Spindle Microtubules To Kinetochore DNA-templated Transcription, Initiation RNA Biosynthetic Process Chromosome Organization Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Localization To Chromosome, Centromeric Region Attachment Of Spindle Microtubules To Kinetochore Regulation Of Phosphorylation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Cell Cycle Receptor Catabolic Process Mitotic Sister Chromatid Cohesion Enucleate Erythrocyte Differentiation RNA Metabolic Process Chromatin Silencing At RDNA Positive Regulation Of Chromosome Segregation Regulation Of Phosphorus Metabolic Process Regulation Of Sister Chromatid Cohesion Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Hepatocyte Apoptotic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process	Apoptotic Process Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Cell Death Regulation Of Signaling Muscle Filament Sliding Actin-myosin Filament Sliding Developmental Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Anatomical Structure Development Organ Development Response To Organic Substance Actin-mediated Cell Contraction Cell Differentiation Cell Development Protein Localization To Nucleus Protein Localization To Organelle System Development Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Muscle Contraction Response To External Stimulus Anatomical Structure Morphogenesis Cellular Response To Stimulus Cell Activation Regulation Of Cellular Process Muscle System Process Axon Guidance Positive Regulation Of Transport Blood Coagulation Hemostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Localization Rhythmic Process Platelet Activation Wound Healing Negative Regulation Of Cell Death Positive Regulation Of Cell Death Regulation Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Response To Stress
Tagcloud ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic	5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Difference) ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic	5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Intersection) ?