ACTN2 and LRRC7

Number of citations of the paper that reports this interaction (PMID 16120608)
37

Data Source:
HPRD (in vitro)

		ACTN2	LRRC7
Gene Name		actinin, alpha 2	leucine rich repeat containing 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Actin Filament Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Vesicular Exosome	Cytoplasm Postsynaptic Density Cell Junction Postsynaptic Membrane
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle LIM Domain Binding Thyroid Hormone Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Protein Dimerization Activity Actin Filament Binding FATZ Binding Titin Z Domain Binding	Protein Binding
	Biological Process	Platelet Degranulation Cell Adhesion Synaptic Transmission Blood Coagulation Microspike Assembly Muscle Filament Sliding Platelet Activation Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Focal Adhesion Assembly Protein Homotetramerization Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Receptor Activity
Pathways		Striated Muscle Contraction Platelet degranulation CREB phosphorylation through the activation of Ras Activation of NMDA receptor upon glutamate binding and postsynaptic events Response to elevated platelet cytosolic Ca2+ CREB phosphorylation through the activation of CaMKII Nephrin interactions Platelet activation, signaling and aggregation Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 21784300) Hypertension risk in short sleep duration ( 22322875) Obesity-related traits ( 23251661) Orofacial clefts ( 22419666)
Protein-Protein Interactions		59 interactors: ACTN3 ADAM12 ADORA2A ANG ATXN2 ATXN7 BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 COIL DISC1 DLG1 DLG4 EPS8L1 ERBB2IP FAM154A FBXL22 GRIN1 GRIN2B ITGB3BP KAT2B KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MED14 MICALL2 MOS MYOZ1 MYOZ2 MYOZ3 MYPN NCOA2 NCOR1 NOS3 NR1I2 NRIP1 PALLD PDLIM1 PDLIM3 PKD2 RAVER1 RPL35 RTP5 SELE SNAI1 SNW1 SP100 SSX2IP ST7 SYNPO2 TNN TTN UTRN ZNF446	11 interactors: ACTN2 ACTN4 BAI1 CAMK2A CAMK2G CDH2 CNKSR2 CTNND2 HOMEZ NQO2 TOR1A
Entrez ID		88	57554
HPRD ID		00019	09930
Ensembl ID		ENSG00000077522	ENSG00000033122
Uniprot IDs		B2RCS5 P35609 Q59FD9	Q96NW7
PDB IDs		1H8B 1HCI 1QUU
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Regulation Of Ion Transport Organelle Organization Cell Communication Actin Filament-based Process Signaling Cellular Component Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Ion Transmembrane Transport Anatomical Structure Development Synaptic Transmission Positive Regulation Of Metabolic Process Cell Development Signal Transduction Movement Of Cell Or Subcellular Component Cell Differentiation Cell-cell Signaling Regulation Of Cellular Process Rhythmic Process Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Actin Cytoskeleton Organization Anatomical Structure Morphogenesis Protein Complex Assembly Regulation Of Potassium Ion Transport Striated Muscle Cell Differentiation Regulation Of Signaling Anatomical Structure Formation Involved In Morphogenesis Response To Organic Substance Regulation Of Sodium Ion Transport Response To Abiotic Stimulus Muscle System Process Negative Regulation Of Transport Striated Muscle Cell Development Positive Regulation Of Cellular Biosynthetic Process Myofibril Assembly Establishment Or Maintenance Of Apical/basal Cell Polarity Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Muscle Cell Development Cellular Calcium Ion Homeostasis Regulation Of Receptor Internalization Regulation Of Cellular Response To Heat Response To Stimulus Regulation Of Histone Deacetylase Activity Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Locomotion Negative Regulation Of Ion Transport	Regulation Of Ion Transport Regulation Of Protein Localization To Cell Surface Regulation Of Cellular Response To Heat Positive Regulation Of Ion Transport Cell Junction Assembly Cell-cell Junction Organization Synaptic Transmission Cell Adhesion Positive Regulation Of Transport Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Regulation Of Synaptic Transmission Cellular Response To Heat Platelet Degranulation Cell-cell Signaling Positive Regulation Of Ion Transmembrane Transport Adherens Junction Organization Protein Oligomerization Cellular Component Assembly Positive Regulation Of Endocytosis Regulation Of Signaling Response To Heat Establishment Of Localization In Cell Protein Localization To Tight Junction Positive Regulation Of Synaptic Vesicle Endocytosis Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Pinocytosis ER-associated Misfolded Protein Catabolic Process Secretion By Cell Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Sodium:proton Antiporter Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cellular Response To Interferon-gamma Nuclear Membrane Organization Wound Healing G1/S Transition Of Mitotic Cell Cycle Regulation Of Synaptic Plasticity Regulation Of Synaptic Vesicle Endocytosis Regulation Of Sodium:proton Antiporter Activity Microspike Assembly Peroxisome Proliferator Activated Receptor Signaling Pathway Secretion Response To Interferon-gamma Cellular Localization Regulation Of Relaxation Of Cardiac Muscle Regulation Of Endocytosis Response To Temperature Stimulus Regulation Of Calcium Ion Transport Response To Wounding
Tagcloud ?		actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Difference) ?		actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Intersection) ?