TNFRSF11A and MAP3K7

Number of citations of the paper that reports this interaction (PMID 11809792)
28

Data Source:
HPRD (in vivo)

		TNFRSF11A	MAP3K7
Gene Name		tumor necrosis factor receptor superfamily, member 11a, NFKB activator	mitogen-activated protein kinase kinase kinase 7
Image
Gene Ontology Annotations	Cellular Component	External Side Of Plasma Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Cytoplasm Cytosol Plasma Membrane IkappaB Kinase Complex Endosome Membrane
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Cytokine Binding Metal Ion Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Scaffold Protein Binding
	Biological Process	Ossification Adaptive Immune Response Monocyte Chemotaxis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Response To Radiation Osteoclast Differentiation Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Tumor Necrosis Factor Positive Regulation Of JUN Kinase Activity Lymph Node Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Circadian Temperature Homeostasis Mammary Gland Alveolus Development Response To Interleukin-1 Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling	Activation Of MAPKK Activity Activation Of MAPK Activity Angiogenesis Neural Tube Formation Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity I-kappaB Phosphorylation JNK Cascade Positive Regulation Of Interleukin-2 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Histone H3 Acetylation Innate Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways			Signaling by the B Cell Receptor (BCR) Downstream TCR signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Toll Like Receptor 7/8 (TLR7/8) Cascade Signaling by Wnt Toll Like Receptor TLR6:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system MyD88-independent cascade beta-catenin independent WNT signaling Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Ca2+ pathway Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Bone mineral density (spine) ( 19801982) Paget's disease ( 21623375 20436471) Response to antipsychotic treatment ( 23241943) Serum albumin level ( 23022100)	Celiac disease ( 20190752) Graves' disease ( 21841780)
Protein-Protein Interactions		13 interactors: CBL CBLB FHL2 GAB2 MAP3K7 SRC TAB2 TNFSF11 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6	60 interactors: BBS10 BCL10 CARD11 CHUK COPS5 EIF2AK2 EZH2 FOS GPR25 HGS HIPK2 IKBKAP IKBKB IL17RD IRAK1 MAP2K4 MAP2K6 MAP3K14 MAP3K3 MAP3K5 MAP4K1 MAP4K4 MAPK14 MAPK6 MAPK8 MAPK8IP1 MAVS NAIP NDUFS6 NOD2 NRIP1 PEBP1 PELI3 PINK1 PPM1B PPM1L PPP2R1A PPP5C PRKAA1 PRKAB1 RBX1 RELA RNF19A ROR2 SMAD3 SMAD6 SMAD7 STAT3 STRADB TAB1 TAB2 TGFBR1 TNFRSF11A TRAF3IP2 TRAF6 TRIM8 VRK2 XIAP ZNF593 ZNF746
Entrez ID		8792	6885
HPRD ID		04609	04011
Ensembl ID		ENSG00000141655	ENSG00000135341
Uniprot IDs		I4EC36 I4EC38 N0GVH0 Q59EP9 Q9Y6Q6	O43318
PDB IDs		1LB5	2EVA 2YIY 4GS6 4L3P 4L52 4L53
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of MAP Kinase Activity Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Activation Of Protein Kinase Activity Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Apoptotic Process Osteoclast Differentiation Signaling Activation Of Innate Immune Response Cell Communication Regulation Of Signaling Regulation Of Cell Death Positive Regulation Of Immune Response Regulation Of Cell-cell Adhesion I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Lymphocyte Activation Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of T Cell Activation Positive Regulation Of MAPK Cascade Cellular Response To Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Innate Immune Response Positive Regulation Of Protein Kinase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of JUN Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of T Cell Cytokine Production	Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Signal Transduction By Phosphorylation Signal Transduction Regulation Of Phosphorylation MAPK Cascade Regulation Of Protein Metabolic Process Signaling Regulation Of Phosphorus Metabolic Process Cell Communication Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of MAPK Cascade Phosphorylation Intracellular Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Protein Phosphorylation Toll-like Receptor 9 Signaling Pathway Stress-activated MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Stimulus MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Response To Stimulus Regulation Of MAP Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Innate Immune Response
Tagcloud ?		allelic atg autophagy becn1 contexts cooperation delays fvb heterozygosity implicating mammary mmtv monoallelic multiparous nfkb nonautophagy palb2 paradoxical parity pymt questioned seemingly suppressive tnbcs tumorigenesis wingless wnt1	abrogated accounts bcr called card card11 carma1 existence feedback generating ikappab ikk ikkbeta implies kappab late maguk mathematical modeling module nf residue scaffolding serine steep switch switchlike tak1 threshold
Tagcloud (Difference) ?		allelic atg autophagy becn1 contexts cooperation delays fvb heterozygosity implicating mammary mmtv monoallelic multiparous nfkb nonautophagy palb2 paradoxical parity pymt questioned seemingly suppressive tnbcs tumorigenesis wingless wnt1	abrogated accounts bcr called card card11 carma1 existence feedback generating ikappab ikk ikkbeta implies kappab late maguk mathematical modeling module nf residue scaffolding serine steep switch switchlike tak1 threshold
Tagcloud (Intersection) ?