TNFRSF14 and NDUFS2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TNFRSF14	NDUFS2
Gene Name		tumor necrosis factor receptor superfamily, member 14	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Carrier Activity Metal Ion Binding Quinone Binding NAD Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Positive Regulation Of Cytokine Secretion Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway Response To Virus Viral Process T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of T Cell Migration	Mitochondrial Electron Transport, NADH To Ubiquinone Response To Oxidative Stress Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Costimulation by the CD28 family Adaptive Immune System	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH
Diseases
GWAS		Celiac disease ( 20190752) Rheumatoid arthritis ( 18794853 20453842) Ulcerative colitis ( 23128233 21297633)
Protein-Protein Interactions		30 interactors: A2M APP BTLA CD160 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 KIAA1377 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48	5 interactors: APP CENPU EGR2 HMOX2 TNFRSF14
Entrez ID		8764	4720
HPRD ID		04122	04285
Ensembl ID		ENSG00000157873	ENSG00000158864
Uniprot IDs		Q92956	B7Z792 O75306
PDB IDs		1JMA 2AW2 4FHQ
Enriched GO Terms of Interacting Partners?		Signal Transduction Apoptotic Process Programmed Cell Death Signaling Cell Communication Cell Death Death Cellular Response To Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteolysis Regulation Of Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Immune Response Regulation Of Endopeptidase Activity Regulation Of Immune System Process Regulation Of Peptidase Activity Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription Factor Import Into Nucleus Response To Stress Negative Regulation Of Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Peptidase Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cell Activation Histone H4 Deacetylation Positive Regulation Of NF-kappaB Transcription Factor Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Immune System Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Protein Binding Negative Regulation Of Proteolysis Positive Regulation Of Adaptive Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Histone H3 Deacetylation Negative Regulation Of Protein Processing Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Modification Regulation Of Establishment Of Protein Localization	Rhombomere 5 Formation Rhombomere 3 Formation Transition Metal Ion Homeostasis Rhombomere 3 Morphogenesis Synaptic Growth At Neuromuscular Junction Brain Segmentation Collateral Sprouting In Absence Of Injury Heme Oxidation Regulation Of Peptidyl-tyrosine Phosphorylation Rhombomere 3 Development Rhombomere 5 Development Positive Regulation Of Cytokine Secretion Involved In Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Rhombomere Morphogenesis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Learning Or Memory Axon Choice Point Recognition Locomotion Cognition Negative Regulation Of Alpha-beta T Cell Proliferation Heme Catabolic Process Neuron Remodeling Rhombomere Development Facial Nerve Structural Organization Regulation Of Cytokine Secretion Involved In Immune Response Axon Guidance Facial Nerve Morphogenesis Regulation Of Cellular Amino Acid Metabolic Process Cellular Metal Ion Homeostasis Response To Oxidative Stress Cellular Cation Homeostasis Cellular Ion Homeostasis Positive Regulation Of T Cell Migration Single-organism Behavior Metal Ion Homeostasis Cellular Copper Ion Homeostasis Response To External Stimulus Rhythmic Behavior Regulation Of T Cell Migration Parasympathetic Nervous System Development Regulation Of Cellular Ketone Metabolic Process Anatomical Structure Arrangement Copper Ion Homeostasis Suckling Behavior Axonogenesis Cellular Chemical Homeostasis Negative Regulation Of Alpha-beta T Cell Activation Viral Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?		aberrations additional advances approaches biological closely contribute crebbp ep300 epha7 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology translocation understanding unique	accounting agf3l2 assembly c20orf7 c8orf38 chase confirming docks holoenzyme immunoprecipitated knock knocked labeling module mtdna nadh nd1 ndufa9 ndufaf3 ndufaf4 nucleating oxidoreductase proteolysis pulse redundant stabilizes ubiquinone
Tagcloud (Difference) ?		aberrations additional advances approaches biological closely contribute crebbp ep300 epha7 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology translocation understanding unique	accounting agf3l2 assembly c20orf7 c8orf38 chase confirming docks holoenzyme immunoprecipitated knock knocked labeling module mtdna nadh nd1 ndufa9 ndufaf3 ndufaf4 nucleating oxidoreductase proteolysis pulse redundant stabilizes ubiquinone
Tagcloud (Intersection) ?