TNFSF14 and LTB

Number of citations of the paper that reports this interaction (PMID 10318773)
55

Data Source:
HPRD (in vitro)

		TNFSF14	LTB
Gene Name		tumor necrosis factor (ligand) superfamily, member 14	lymphotoxin beta (TNF superfamily, member 3)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane	Cellular_component Extracellular Space Integral Component Of Membrane
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding
	Biological Process	Apoptotic Process Immune Response Signal Transduction Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of T Cell Chemotaxis T Cell Costimulation T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Myoblast Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Myoblast Fusion	Immune Response Signal Transduction Cell-cell Signaling Gene Expression Skin Development Positive Regulation Of Interleukin-12 Biosynthetic Process Lymph Node Development
Pathways
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)	AIDS progression ( 19115949) Crohn's disease ( 21102463) Neonatal lupus ( 20662065)
Protein-Protein Interactions		5 interactors: APP LTB LTBR TNFRSF14 TNFRSF6B	4 interactors: LTA LTBR TNFRSF1A TNFSF14
Entrez ID		8740	4050
HPRD ID		05157	02987
Ensembl ID		ENSG00000125735	ENSG00000227507
Uniprot IDs		O43557	Q06643 Q5STB2
PDB IDs		4EN0 4J6G 4KG8 4KGG 4KGQ
Enriched GO Terms of Interacting Partners?		Programmed Cell Death Cell Death Death Immune System Process Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Positive Regulation Of Cellular Metabolic Process Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cytokine Secretion Involved In Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Axon Choice Point Recognition Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Regulation Of Phosphorylation Neuron Remodeling Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of T Cell Migration Lymph Node Development Cellular Copper Ion Homeostasis Response To External Stimulus Regulation Of T Cell Migration Regulation Of Cellular Ketone Metabolic Process Copper Ion Homeostasis Suckling Behavior Regulation Of Cytokine Production Negative Regulation Of Alpha-beta T Cell Activation Viral Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Myeloid Dendritic Cell Differentiation Myeloid Dendritic Cell Activation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Lymphocyte Migration Regulation Of Protein Metabolic Process Mating Behavior Defense Response To Gram-negative Bacterium Endoplasmic Reticulum Calcium Ion Homeostasis Tumor Necrosis Factor-mediated Signaling Pathway Cell Activation	Cellular Response To Mechanical Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Response To Mechanical Stimulus Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Death Death Response To Abiotic Stimulus Regulation Of Apoptotic Process Regulation Of Cell Death Response To External Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Inflammatory Response Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Defense Response To Bacterium Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Release Of Cytoplasmic Sequestered NF-kappaB Regulation Of Inflammatory Response Response To Hypoxia Response To Lipopolysaccharide Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of T Cell Chemotaxis Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Intracellular Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Chronic Inflammatory Response Response To Bacterium Signal Transduction Leukocyte Activation Positive Regulation Of Glial Cell Proliferation
Tagcloud ?		17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck xcl1	31p anova burdens cachexia fall fisher fructose gluconeogenic hepatic infused infusion inoculated inorganic methylcholanthrene monitored mrs noninvasively permit phosphomonoesters pi pme prefructose reflecting remote return returned seventeen triphosphate tumour
Tagcloud (Difference) ?		17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck xcl1	31p anova burdens cachexia fall fisher fructose gluconeogenic hepatic infused infusion inoculated inorganic methylcholanthrene monitored mrs noninvasively permit phosphomonoesters pi pme prefructose reflecting remote return returned seventeen triphosphate tumour
Tagcloud (Intersection) ?