KISS1R and KISS1

Number of citations of the paper that reports this interaction (PMID 11457843)
171

Data Source:
HPRD (in vitro, in vivo)

		KISS1R	KISS1
Gene Name		KISS1 receptor	KiSS-1 metastasis-suppressor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane	Extracellular Region
	Molecular Function	Protein Binding Neuropeptide Receptor Activity Neuropeptide Binding	Protein Binding
	Biological Process	Activation Of MAPKK Activity G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Negative Regulation Of Cell Proliferation Calcium-mediated Signaling Positive Regulation Of Hormone Secretion Arachidonic Acid Secretion Positive Regulation Of Synaptic Transmission Positive Regulation Of Stress Fiber Assembly	Cytoskeleton Organization
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: KISS1	7 interactors: APP KISS1R MMP14 MMP16 MMP2 MMP24 MMP9
Entrez ID		84634	3814
HPRD ID		09167	04475
Ensembl ID		ENSG00000116014	ENSG00000170498
Uniprot IDs		Q969F8	Q15726
PDB IDs
Enriched GO Terms of Interacting Partners?			Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Endoderm Formation Ossification Endoderm Development Chondrocyte Proliferation Formation Of Primary Germ Layer Craniofacial Suture Morphogenesis Skeletal System Development Gastrulation Embryonic Morphogenesis Proteolysis Positive Regulation Of Catalytic Activity Neurogenesis Response To External Stimulus Skeletal System Morphogenesis Endochondral Ossification Response To Abiotic Stimulus Axon Guidance Nervous System Development Embryonic Cranial Skeleton Morphogenesis Embryo Development System Development Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Embryo Implantation Locomotion Endochondral Bone Morphogenesis Reproductive Process Ephrin Receptor Signaling Pathway Axonogenesis Multicellular Organismal Development Axon Development Anatomical Structure Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Organ Development Bone Morphogenesis Synaptic Growth At Neuromuscular Junction Embryonic Skeletal System Morphogenesis Neuron Projection Morphogenesis Regulation Of Protein Binding Positive Regulation Of Peptidase Activity
Tagcloud ?		ahead alleles beyond compelling critically decade discusses embryo fertility follicular hypothalamic implantation implicating kisspeptin lie mammals manipulated neuroendocrine oocyte ovulation placentation playing powerful reproductive researchers steroid strides tremendous	ahead alleles beyond compelling critically decade discusses embryo fertility follicular hypothalamic implantation implicating kisspeptin lie mammals manipulated neuroendocrine oocyte ovulation placentation playing powerful reproductive researchers steroid strides tremendous
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		ahead alleles beyond compelling critically decade discusses embryo fertility follicular hypothalamic implantation implicating kisspeptin lie mammals manipulated neuroendocrine oocyte ovulation placentation playing powerful reproductive researchers steroid strides tremendous