KLF11 and APH1A

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		KLF11	APH1A
Gene Name		Kruppel-like factor 11	APH1A gamma secretase subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Golgi Cisterna Membrane
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Transcription Regulatory Region DNA Binding Metal Ion Binding	Endopeptidase Activity Protein Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Cellular Response To Peptide	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Apoptotic Signaling Pathway
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		12 interactors: APH1A APPBP2 ATXN1 CBX1 CBX3 CLU HDAC1 MAPK1 SIN3A TIMM13 TXNDC9 YWHAZ	15 interactors: ATF4 BHLHE40 GLP1R GPATCH8 HES1 HIVEP1 KLF11 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 THPO TLE1 TMED10
Entrez ID		8462	51107
HPRD ID		04488	06360
Ensembl ID		ENSG00000172059	ENSG00000117362
Uniprot IDs		B7ZAX4 O14901 Q53QU8	B4DUG7 Q96BI3
PDB IDs		1PO4
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cellular Localization Platelet Activation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Protein Localization Neurotrophin Signaling Pathway Establishment Of Localization In Cell Negative Regulation Of Cellular Metabolic Process Cytoplasmic Transport Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Protein Localization Protein Transport Protein Targeting To Mitochondrion Rhythmic Process Regulation Of Apoptotic Process Establishment Of Protein Localization Histone Deacetylation Protein Localization To Mitochondrion Protein Deacetylation Positive Regulation Of Tau-protein Kinase Activity Regulation Of Neuronal Signal Transduction Response To Methylglyoxal Microglial Cell Proliferation Negative Regulation Of Histone H3-K27 Acetylation Intracellular Transport Regulation Of Cell Death Establishment Of Protein Localization To Organelle Apoptotic Signaling Pathway Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cellular Biosynthetic Process Intracellular Protein Transport Negative Regulation Of Apoptotic Process Mitochondrion Organization Negative Regulation Of Programmed Cell Death MAPK Import Into Nucleus Positive Regulation Of Neurofibrillary Tangle Assembly Apoptotic Process Protein Targeting Negative Regulation Of Cell Death Programmed Cell Death Cell Death Death	Amyloid Precursor Protein Catabolic Process Notch Signaling Pathway Amyloid Precursor Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Membrane Protein Proteolysis Beta-amyloid Metabolic Process Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Metabolic Process Positive Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Neural Tube Patterning Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Protein Processing Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Neuron Development Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Programmed Cell Death Cell Morphogenesis Involved In Neuron Differentiation Cell Death Death Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Neuron Differentiation Response To Stimulus Response To Organic Substance Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Involved In Differentiation Cellular Response To Organic Substance Locomotion Peptide Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Transcription From RNA Polymerase II Promoter Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Dorsal/ventral Neural Tube Patterning Cellular Nitrogen Compound Metabolic Process Movement Of Cell Or Subcellular Component
Tagcloud ?		adenovirus adhesion augments coding constitutes ec ecs emerging exhibit inhibits interfering knockdown kruppel leukocyte lipopolysaccharide maturity mechanistically mellitus mody7 necrosis neonatal organism p65 potently proinflammatory promoters selectin uncovered vascular	aph1b belonging categorize clarify cleave consequently exclusive fall gamma heterogeneous histopathological implying intensively kaplan meier mutually nicastrin pen presenilin probability probable proteolytically secretase transmembrane treatable triple ubiquitously univariate
Tagcloud (Difference) ?		adenovirus adhesion augments coding constitutes ec ecs emerging exhibit inhibits interfering knockdown kruppel leukocyte lipopolysaccharide maturity mechanistically mellitus mody7 necrosis neonatal organism p65 potently proinflammatory promoters selectin uncovered vascular	aph1b belonging categorize clarify cleave consequently exclusive fall gamma heterogeneous histopathological implying intensively kaplan meier mutually nicastrin pen presenilin probability probable proteolytically secretase transmembrane treatable triple ubiquitously univariate
Tagcloud (Intersection) ?