CARD11 and WDR1

Number of citations of the paper that reports this interaction (PMID 17293856)
23

Data Source:
HPRD (in vivo)

		CARD11	WDR1
Gene Name		caspase recruitment domain family, member 11	WD repeat domain 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane T Cell Receptor Complex Membrane Raft Extracellular Vesicular Exosome	Podosome Extracellular Region Cytoplasm Cytosol Actin Filament Cell Junction Cell Projection Extracellular Vesicular Exosome
	Molecular Function	Guanylate Kinase Activity Protein Binding CARD Domain Binding	Actin Binding
	Biological Process	Positive Regulation Of Cytokine Production Positive Regulation Of B Cell Proliferation T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Thymic T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation Nucleotide Phosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity	Platelet Degranulation Blood Coagulation Sensory Perception Of Sound Platelet Activation Regulation Of Oligodendrocyte Differentiation
Pathways		Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) TCR signaling FCERI mediated NF-kB activation Downstream TCR signaling Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling Adaptive Immune System Innate Immune System	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Atopic dermatitis ( 23042114) Ulcerative colitis ( 23128233) White matter integrity ( 23218918)	Cardiovascular disease risk factors ( 21943158) Urate levels ( 18179892) Uric acid levels ( 21294900 22229870)
Protein-Protein Interactions		10 interactors: BCL10 IKBKG MAP3K7 PDPK1 PRKCB PRKCQ SH2D3C TAB1 WDR1 ZAP70	5 interactors: CARD11 CFL1 CSNK2B GRB2 SKIV2L
Entrez ID		84433	9948
HPRD ID		06234	09199
Ensembl ID		ENSG00000198286	ENSG00000071127
Uniprot IDs		Q8TES3 Q9BXL7	O75083
PDB IDs
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune Response Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune System Process Response To Stress Innate Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell-cell Adhesion JNK Cascade Regulation Of Signal Transduction Phosphorylation Intracellular Signal Transduction Regulation Of T Cell Activation Positive Regulation Of Cell Activation Toll-like Receptor Signaling Pathway Regulation Of Signaling Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Signal Transduction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Immune Response Immune System Process Pattern Recognition Receptor Signaling Pathway Defense Response Innate Immune Response-activating Signal Transduction Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Activation Of Innate Immune Response Regulation Of Lymphocyte Activation Positive Regulation Of Intracellular Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Activation Positive Regulation Of Innate Immune Response Apoptotic Process Platelet Activation Programmed Cell Death Regulation Of Intracellular Signal Transduction	Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Immune Response-regulating Signaling Pathway Morphogenesis Of An Epithelium T Cell Costimulation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Positive Regulation Of Immune Response Neuron Projection Morphogenesis Tissue Morphogenesis Cell Activation Cell Morphogenesis Involved In Differentiation Innate Immune Response Neuron Projection Development Cell Projection Morphogenesis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Part Morphogenesis Regulation Of Immune Response Positive Regulation Of Immune System Process Neuron Development Platelet Activation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Ras Protein Signal Transduction Cell Morphogenesis Epithelium Development Fc-epsilon Receptor Signaling Pathway Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Cell Projection Organization Phagocytosis Locomotion Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of T Cell Activation Immune Response Regulation Of Immune System Process Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Cell Activation Defense Response Adiponectin-activated Signaling Pathway
Tagcloud ?		7q baffr characterise clustered cooperative deregulate doi exome frameshift genetics ighv1 inactivating indels klf2 kruppel leu lymphomagenesis marginal missense myd88 nonsense notch2 publication smzl smzls splenic tnfaip3 tnfr traf3	actb actr3 anxa2 anxa6 canine cope dedifferentiation grade histologically hspa9 interesting kit mast mct mcts mutational noteworthy observable oncology paradox pdia3 proliferating proteome reflected tcp1a tcp1e transferrin tryptase tumours
Tagcloud (Difference) ?		7q baffr characterise clustered cooperative deregulate doi exome frameshift genetics ighv1 inactivating indels klf2 kruppel leu lymphomagenesis marginal missense myd88 nonsense notch2 publication smzl smzls splenic tnfaip3 tnfr traf3	actb actr3 anxa2 anxa6 canine cope dedifferentiation grade histologically hspa9 interesting kit mast mct mcts mutational noteworthy observable oncology paradox pdia3 proliferating proteome reflected tcp1a tcp1e transferrin tryptase tumours
Tagcloud (Intersection) ?