BCAR3 and ERBB3

Number of citations of the paper that reports this interaction (PMID 16273093)
170

Data Source:
BioGRID (unspecified method)

		BCAR3	ERBB3
Gene Name		breast cancer anti-estrogen resistance 3	erb-b2 receptor tyrosine kinase 3
Image
Gene Ontology Annotations	Cellular Component		Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Receptor Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Lens Morphogenesis In Camera-type Eye Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Response To Drug Positive Regulation Of GTPase Activity	Endocardial Cushion Development Protein Phosphorylation Negative Regulation Of Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Peripheral Nervous System Development Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Signal Transduction Schwann Cell Differentiation Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cranial Nerve Development Fc-epsilon Receptor Signaling Pathway Wound Healing Regulation Of Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Protein Tyrosine Kinase Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Type 1 diabetes ( 19430480 18198356 17554260 17554300 18978792) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 22951725)
Protein-Protein Interactions		6 interactors: APP ERBB2 ERBB3 KPNA1 NEDD9 RPRD1A	66 interactors: ABL1 ABL2 AGTR2 BCAR3 CD82 CDK5 CHN2 CRK CRKL DAB1 DAPP1 EGF EGFR EGR1 ERBB2 ERBB4 FER FGFR1 FLNA FLYWCH1 GRB2 GRB7 HCK HDAC6 IL6ST ITK JAK2 JAK3 MUC1 NCK1 NCK2 NEDD4 NRG1 NRG2 ODF2L PA2G4 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTGES3 PTK2 PTK2B PTK6 RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 SH2B3 SH2D1A SHC1 SHC3 SOS1 SRC SYK TNS2 TNS3 TNS4 TXK VAV1 VAV2 VAV3 ZAP70 ZNF207
Entrez ID		8412	2065
HPRD ID		05268	01820
Ensembl ID		ENSG00000137936	ENSG00000065361
Uniprot IDs		B3KNL6 B3KP06 O75815	P21860
PDB IDs		3T6A	1M6B 2L9U 3KEX 3LMG 3P11 4LEO
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol 3-kinase Signaling Neuromuscular Junction Development Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Neuron Death Cell Surface Receptor Signaling Pathway Peripheral Nervous System Development Wound Healing Regulation Of Growth Response To Wounding Synaptic Growth At Neuromuscular Junction Phosphatidylinositol-mediated Signaling Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Innate Immune Response Synapse Organization Glial Cell Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Immature T Cell Proliferation In Thymus Dephosphorylation Of RNA Polymerase II C-terminal Domain Response To Fibroblast Growth Factor Negative Regulation Of Cell Adhesion Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Gliogenesis Cell Death Death Regulation Of Protein Phosphorylation Axon Choice Point Recognition Positive Regulation Of Cellular Protein Metabolic Process Fc Receptor Signaling Pathway Regulation Of Translation Regulation Of Nitrogen Compound Metabolic Process Peptidyl-tyrosine Phosphorylation Negative Regulation Of T Cell Differentiation In Thymus Neuron Remodeling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase III Promoter Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Cell Communication Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Signaling Regulation Of Signaling Cell Migration Signal Transduction Immune Response Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Cell Motility Locomotion Positive Regulation Of Signal Transduction Regulation Of Immune System Process Intracellular Signal Transduction Defense Response Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Cellular Response To Stimulus Regulation Of Kinase Activity Regulation Of Catalytic Activity Fc-epsilon Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Cell Activation Response To Growth Factor Response To Stress Positive Regulation Of Catalytic Activity Response To Stimulus Wound Healing Response To Organic Substance Cellular Response To Growth Factor Stimulus Regulation Of Cell Proliferation Blood Coagulation Hemostasis
Tagcloud ?		adjuvant bcl2 cohorts dutch easily endpoint esr1 favorable implemented indicative mann menopausal naive nat1 ncoa1 pfs pgr predictive promise qpcr select setting signatures start stratify tamoxifen transcriptase univariate whitney	acquire alteration associate cascades concurrent dependence egf enhancing latent mapk mediators p42 p44 phosphotyrosine potentiates potentiating predicts prime priming progestin progestins r5020 shc shift stat5 steroid switches synergistically waf1
Tagcloud (Difference) ?		adjuvant bcl2 cohorts dutch easily endpoint esr1 favorable implemented indicative mann menopausal naive nat1 ncoa1 pfs pgr predictive promise qpcr select setting signatures start stratify tamoxifen transcriptase univariate whitney	acquire alteration associate cascades concurrent dependence egf enhancing latent mapk mediators p42 p44 phosphotyrosine potentiates potentiating predicts prime priming progestin progestins r5020 shc shift stat5 steroid switches synergistically waf1
Tagcloud (Intersection) ?