PRAM1 and ABI2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PRAM1	ABI2
Gene Name		PML-RARA regulated adaptor molecule 1	abl-interactor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm Cytosol Cytoskeleton Lamellipodium Filopodium SCAR Complex
	Molecular Function	Protein Binding Lipid Binding	DNA Binding Protein Binding Cytoskeletal Adaptor Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Rac GTPase Binding Proline-rich Region Binding
	Biological Process		Movement Of Cell Or Subcellular Component Cytoskeleton Organization Actin Polymerization Or Depolymerization Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways			Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Height ( 18391951)	Butyrylcholinesterase levels ( 21862451) Subclinical atherosclerosis traits (other) ( 17903303)
Protein-Protein Interactions		19 interactors: A2M ABI2 APOE APP CCDC57 CDC37 FXR2 KRT40 LCP2 LYN MAST1 MXD1 NEK6 PSEN1 RNF32 SKAP1 SKAP2 TRIM27 UBE2E2	57 interactors: ABL1 ADAM19 AES ARHGAP32 ARMC7 BLOC1S6 CCDC102B CCDC36 CCDC53 CCHCR1 CDK6 CRX DTNB EFS EGLN3 EIF3H ENAH GCC1 HGS HNRNPK HOMER3 IFT20 KHDRBS1 KIAA1217 KIFC3 KRT13 KRT15 KRT19 KRT20 KRT31 KRT33B LMO2 MRFAP1L1 MRPL44 NCK2 NUP62 PCM1 PIN1 PPIF PRAM1 PRKAA1 PRKAA2 PRR16 SDCBP SH3KBP1 SNAP23 STAM2 TFIP11 TRAF3IP1 TRIM32 TRIP6 VARS2 VASP VCL VPS37C WASF2 WIPF1
Entrez ID		84106	10152
HPRD ID		05926	07338
Ensembl ID		ENSG00000133246	ENSG00000138443
Uniprot IDs		Q96QH2	E9PEZ7 Q9NYB9
PDB IDs			2ED0 3P8C
Enriched GO Terms of Interacting Partners?		Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cytokine Secretion Establishment Of Localization In Cell Antigen Receptor-mediated Signaling Pathway Secretion Regulation Of Protein Metabolic Process Cell Activation Regulation Of Protein Kinase Activity Cellular Localization Negative Regulation Of Catalytic Activity Platelet Activation Regulation Of Kinase Activity Signal Transduction Negative Regulation Of Protein Kinase Activity Regulation Of Immune System Process Cellular Response To Stimulus Platelet Degranulation Negative Regulation Of Kinase Activity Regulation Of Cellular Process Regulation Of Signal Transduction Signaling Neuron Development Negative Regulation Of Cellular Metabolic Process Cell Communication Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation T Cell Receptor Signaling Pathway Regulation Of Signaling Regulation Of Proteolysis Neuron Differentiation Exocytosis Response To Wounding Protein Secretion Negative Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Cytokine Production Negative Regulation Of Phosphorylation Response To Stress Cellular Component Assembly Protein Localization Regulation Of Phosphorylation Regulation Of Cellular Component Organization Protein Metabolic Process	Intracellular Transport Organelle Organization Cell Projection Assembly Establishment Of Localization In Cell Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signal Transduction Response To Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Cytoskeleton Organization Negative Regulation Of Signaling Cellular Localization Cellular Component Assembly Regulation Of Signal Transduction Cell Projection Morphogenesis Cellular Response To Stimulus Developmental Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Part Morphogenesis Cell Cycle Arrest Cell Projection Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Actin Cytoskeleton Organization System Development Actin Filament-based Process Anatomical Structure Development Signaling Intraciliary Transport Cell Morphogenesis Membrane Organization Generation Of Neurons Cell Communication Regulation Of Autophagy Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development Protein Localization Protein Transport Neurogenesis Lamellipodium Assembly Signal Transduction Lamellipodium Organization Establishment Of Protein Localization Negative Regulation Of Cellular Senescence Microtubule-based Transport
Tagcloud ?		2b4 acgh annotation c3h cd244 cnv congolense crosses damaging hej hybridisation infect lies livestock mbp plausible protozoan qtl resequencing sickness sleeping snp synonymous tir1 tir2 tir3 tir3c trypanosoma trypanosomes	aba abscisic arabidopsis aux1 auxin axr4 crosstalk ein2 eir1 elongation ethylene eto1 formed2 genotyping germination insensitive insensitive2 operate overproducer1 pin pin2 positional resistant1 resistant4 responsiveness root root1 seed thaliana
Tagcloud (Difference) ?		2b4 acgh annotation c3h cd244 cnv congolense crosses damaging hej hybridisation infect lies livestock mbp plausible protozoan qtl resequencing sickness sleeping snp synonymous tir1 tir2 tir3 tir3c trypanosoma trypanosomes	aba abscisic arabidopsis aux1 auxin axr4 crosstalk ein2 eir1 elongation ethylene eto1 formed2 genotyping germination insensitive insensitive2 operate overproducer1 pin pin2 positional resistant1 resistant4 responsiveness root root1 seed thaliana
Tagcloud (Intersection) ?