BRIP1 and HNRNPC

Number of citations of the paper that reports this interaction (PMID 23585894)
0

Data Source:
BioGRID (unspecified method)

		BRIP1	HNRNPC
Gene Name		BRCA1 interacting protein C-terminal helicase 1	heterogeneous nuclear ribonucleoprotein C (C1/C2)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Membrane	Nuclear Chromatin Nucleus Nucleoplasm Spliceosomal Complex Cytosol Membrane Protein Complex Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Nucleotide Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(U) RNA Binding Nucleosomal DNA Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	DNA Damage Checkpoint Double-strand Break Repair Regulation Of Transcription From RNA Polymerase II Promoter DNA Duplex Unwinding Small Molecule Metabolic Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Splicing Gene Expression ATP-dependent Chromatin Remodeling 3'-UTR-mediated MRNA Stabilization
Pathways		Homologous DNA pairing and strand exchange Cytosolic iron-sulfur cluster assembly Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Bipolar disorder ( 21738484)
Protein-Protein Interactions		6 interactors: BARD1 BLM BRCA1 HNRNPC RPA1 TOPBP1	48 interactors: AP1M1 BARD1 BRCA1 BRCA2 BRIP1 BTRC CCDC85B CDKN2A CELF1 CSNK1A1 CSNK2A1 CSNK2A2 DHX9 EPS8 ERG FAS FXR2 GRB2 HNRNPD IL7R KHDRBS3 KPNA2 KPNA3 KPNA4 KRAS LMO2 LMO3 PALB2 PDGFB PHKB PIN1 PRKDC PTBP2 RAD51 RALY RALYL RBM41 SDCBP SF3B2 SMARCD1 SREK1 SRPK2 SUMO1 SUMO1P1 UBE2I YWHAQ ZFYVE26 ZNF581
Entrez ID		83990	3183
HPRD ID		05797	01243
Ensembl ID			ENSG00000092199
Uniprot IDs		Q9BX63	P07910
PDB IDs		1T29 3AL3	1TXP 1WF2 3LN4
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process Protein K6-linked Ubiquitination Response To Ionizing Radiation Double-strand Break Repair Cellular Response To Stress DNA Recombination DNA Replication G2 DNA Damage Checkpoint Cell Cycle Process Nucleobase-containing Compound Metabolic Process Response To Abiotic Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Cell Cycle Telomere Maintenance Nitrogen Compound Metabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation DNA-dependent DNA Replication Response To Stress Negative Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone H3-K9 Acetylation DNA Catabolic Process DNA Damage Checkpoint Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Cellular Response To Camptothecin Cellular Response To Hydroxyurea Protein Polyubiquitination Tissue Homeostasis Response To Camptothecin Negative Regulation Of Mitotic Recombination Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle DNA Recombinase Assembly Cellular Response To Indole-3-methanol Negative Regulation Of Cell Death Cell Cycle Checkpoint Negative Regulation Of Centriole Replication Regulation Of Mitotic Recombination Multicellular Organismal Homeostasis Chromosome Organization	Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Process Nitrogen Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Stimulus Cell Cycle Double-strand Break Repair Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Regulation Of Cell Cycle Cellular Response To Organic Substance MRNA Processing DNA Repair Cellular Response To Cytokine Stimulus Regulation Of Cellular Process Response To Stimulus Positive Regulation Of Signal Transduction Cellular Response To DNA Damage Stimulus Cellular Response To Stress DNA Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression DNA Recombination Response To Cytokine Regulation Of Protein Metabolic Process MRNA Metabolic Process Response To Organic Substance Regulation Of Cellular Component Organization Response To Ionizing Radiation Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of Cellular Metabolic Process NLS-bearing Protein Import Into Nucleus RNA Processing Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle
Tagcloud ?		alleles atm brca1 brca2 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	17th 2d appreciation coordinately coupling d deep dihydroxyvitamin entitled epigenome exerts expanded extra fine hormones issue linking locations microrna ribonucleoprotein special splicing steroid transcriptionally tuning vdr vdre vitamin workshop
Tagcloud (Difference) ?		alleles atm brca1 brca2 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	17th 2d appreciation coordinately coupling d deep dihydroxyvitamin entitled epigenome exerts expanded extra fine hormones issue linking locations microrna ribonucleoprotein special splicing steroid transcriptionally tuning vdr vdre vitamin workshop
Tagcloud (Intersection) ?