L3MBTL2 and CBX3

Number of citations of the paper that reports this interaction (PMID 21596310)
22

Data Source:
BioGRID (pull down, affinity chromatography technology)

		L3MBTL2	CBX3
Gene Name		l(3)mbt-like 2 (Drosophila)	chromobox homolog 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Condensed Chromosome, Centromeric Region Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin Spindle Nuclear Pericentric Heterochromatin
	Molecular Function	Protein Binding Zinc Ion Binding Methylated Histone Binding Histone Binding	Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Chromatin Modification	Chromatin Remodeling Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: AES CBX3 HIST1H3A HIST1H4A MEAF6 MPP3 PAICS PHF10 PIAS1 RNF2 STAC3 STAM2 TBC1D9B TRIM42	32 interactors: ARL5A ATXN7L2 AURKA AURKB CACNB4 CBX1 CBX5 DNMT3B DSN1 H3F3A HIST1H1E HIST1H3A HIST1H4A HIST3H3 KLF11 L3MBTL1 L3MBTL2 LBR MGA MIS12 MKI67 NIPBL NSL1 PIM1 SP100 TAF4 TRIM24 TRIM28 VHL WHSC1L1 ZNF10 ZNF496
Entrez ID		83746	11335
HPRD ID		13954	05130
Ensembl ID		ENSG00000100395	ENSG00000122565
Uniprot IDs		Q969R5	A4D177 B8ZZ43 Q13185
PDB IDs		2W0T 3CEY 3F70	2L11 3DM1 3KUP 3TZD
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Organization Cellular Nitrogen Compound Metabolic Process Chromatin Silencing At RDNA Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Protein-DNA Complex Assembly Gene Expression Chromosome Organization Chromatin Silencing Chromatin Modification Negative Regulation Of Cellular Metabolic Process DNA Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process RNA Biosynthetic Process DNA Modification Histone Modification Histone H2A-K119 Monoubiquitination Gene Silencing Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Histone H4-K20 Demethylation Regulation Of Cellular Process Nucleosome Assembly Positive Regulation Of Anoikis Chromatin Assembly Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Nucleosome Organization Chromatin Assembly Or Disassembly 'de Novo' IMP Biosynthetic Process Histone H3-K14 Acetylation RNA Metabolic Process Cellular Macromolecular Complex Assembly Chromatin Remodeling DNA Packaging Negative Regulation Of Hematopoietic Progenitor Cell Differentiation	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromosome Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process DNA Methylation Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Organelle Organization DNA Modification Chromatin Silencing Mitotic Cell Cycle Chromatin Silencing At RDNA Mitotic Cell Cycle Process Protein-DNA Complex Assembly Mitotic Nuclear Division Negative Regulation Of Gene Expression, Epigenetic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Gene Expression Regulation Of Gene Expression, Epigenetic Protein Autophosphorylation Nucleobase-containing Compound Metabolic Process Spindle Stabilization Gene Silencing Chromosome Segregation Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleosome Assembly Nitrogen Compound Metabolic Process Chromatin Assembly Cellular Nitrogen Compound Metabolic Process Protein Complex Assembly Nucleosome Organization Cell Cycle Process Chromatin Assembly Or Disassembly DNA Replication-dependent Nucleosome Assembly Transcription, DNA-templated DNA Packaging
Tagcloud ?		700r analyse balancing compaction competent defective dub essentially facilitates flag h2aub1 hek293 integral k675 lethal occupancy occupied polycomb prc1 repressed repressive ring2 seq stably sumo2 sumoylation tagged tails ubiquitinating	1gamma actively assembled biogenesis deformed depleted dnmt3a h3k27 h3k9 heterochromatin hp1gamma linker npm1 nucleolar nucleoli nucleolus organization organized organizer perinucleolar rdna repetitive repressive ribosome silver striking tethering trimethylated u1242mg
Tagcloud (Difference) ?		700r analyse balancing compaction competent defective dub essentially facilitates flag h2aub1 hek293 integral k675 lethal occupancy occupied polycomb prc1 repressed ring2 seq stably sumo2 sumoylation tagged tails ubiquitinating	1gamma actively assembled biogenesis deformed depleted dnmt3a h3k27 h3k9 heterochromatin hp1gamma linker npm1 nucleolar nucleoli nucleolus organization organized organizer perinucleolar rdna repetitive ribosome silver striking tethering trimethylated u1242mg
Tagcloud (Intersection) ?		repressive