CAPZB and MTPN

Number of citations of the paper that reports this interaction (PMID 12488317)
22

Data Source:
HPRD (in vivo)

		CAPZB	MTPN
Gene Name		capping protein (actin filament) muscle Z-line, beta	myotrophin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Actin Filament F-actin Capping Protein Complex Actin Cytoskeleton Sarcomere Actin Cortical Patch Extracellular Vesicular Exosome WASH Complex	Nucleus Cytosol F-actin Capping Protein Complex Axon Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Actin Filament Binding
	Biological Process	Movement Of Cell Or Subcellular Component Cytoskeleton Organization Blood Coagulation Regulation Of Lamellipodium Assembly Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Barbed-end Actin Filament Capping Negative Regulation Of Filopodium Assembly	Regulation Of Translation Catecholamine Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Cell Growth Regulation Of Striated Muscle Tissue Development Cerebellar Granule Cell Differentiation Neuron Differentiation Positive Regulation Of Cell Growth Skeletal Muscle Tissue Regeneration Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Barbed-end Actin Filament Capping
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Crohn's disease and psoriasis ( 22482804) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid volume ( 21565293)
Protein-Protein Interactions		7 interactors: BCCIP HSPA8 MRPL20 MTPN PTN RPP14 VHL	5 interactors: CAPZB MAPK1 NFKB1 REL RELA
Entrez ID		832	136319
HPRD ID		11872	07574
Ensembl ID		ENSG00000077549	ENSG00000105887
Uniprot IDs		B1AK85 B1AK88 B4DWA6 P47756 Q7L4N0	P58546 Q69YG1
PDB IDs			3AAA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Fibril Organization Regulation Of Fibril Organization Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Protein Complex Disassembly Clathrin Coat Disassembly Protein Complex Disassembly Neuroendocrine Cell Differentiation	Regulation Of Interleukin-12 Biosynthetic Process NIK/NF-kappaB Signaling Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of MiRNA Metabolic Process Regulation Of Cytokine Biosynthetic Process Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of MiRNA Metabolic Process Antigen Receptor-mediated Signaling Pathway Activation Of Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Response To Cytokine Positive Regulation Of Innate Immune Response Membrane Protein Intracellular Domain Proteolysis Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Interleukin-6 Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Interleukin-6 Membrane Protein Proteolysis Cellular Response To Peptide Hormone Stimulus Response To Lipopolysaccharide Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Peptide Response To Molecule Of Bacterial Origin Response To Nicotine Cellular Response To Alkaloid Positive Regulation Of Interleukin-12 Production Positive Regulation Of Cytokine Production
Tagcloud ?		actin align apolar capping capza2 cdnas chicken conservation cosedimentation divergence diverges gelsolin homologs leucines mapped monomer outside p36 polar portion q31 regularly severing shares spaced substitutions subunit	ah109a assigned availability backs blockage body breakdown catheterized concluded differ donryu endogenous extraction fractional fsr hepatoma igf inoculated methionine muscle nutrition onto parenteral reducing shift stpn whole wpbr
Tagcloud (Difference) ?		actin align apolar capping capza2 cdnas chicken conservation cosedimentation divergence diverges gelsolin homologs leucines mapped monomer outside p36 polar portion q31 regularly severing shares spaced substitutions subunit	ah109a assigned availability backs blockage body breakdown catheterized concluded differ donryu endogenous extraction fractional fsr hepatoma igf inoculated methionine muscle nutrition onto parenteral reducing shift stpn whole wpbr
Tagcloud (Intersection) ?