DOCK8 and RTP5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DOCK8	RTP5
Gene Name		dedicator of cytokinesis 8	receptor (chemosensory) transporter protein 5 (putative)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Cell Leading Edge	Integral Component Of Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Blood Coagulation Dendritic Cell Migration Positive Regulation Of GTPase Activity Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419) Obesity-related traits ( 23251661)
Protein-Protein Interactions		25 interactors: BYSL CARHSP1 CDC42 CHMP2A DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ KRT40 LRCH1 LRCH3 MED30 MEOX2 MRPL38 MTG1 RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	27 interactors: ACTN2 BEND5 CALCOCO2 CARD9 DOCK8 GOLGA2 HNRNPK KRT40 LZTS2 MDFI MIPOL1 MTUS2 PDE4DIP PNMA1 PNMA2 PSMA3 PSMA6 PSTPIP1 RBPMS RINT1 ROPN1 SP100 SPDL1 SPERT TRAF1 TRIM23 TSGA10
Entrez ID		81704	285093
HPRD ID		10920	08159
Ensembl ID		ENSG00000107099
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	Q14D33
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Morphogenesis Regulation Of Cell Projection Assembly Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Substrate Adhesion-dependent Cell Spreading Anatomical Structure Morphogenesis Posttranscriptional Regulation Of Gene Expression Ribosome Biogenesis Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Filopodium Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Centriole Elongation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Lipid Kinase Activity Anatomical Structure Formation Involved In Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of DNA Replication Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Projection Organization Cell Projection Assembly Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Hair Follicle Cell Proliferation Actin Filament-based Process T Cell Costimulation Positive Regulation Of Cellular Component Biogenesis Ribonucleoprotein Complex Biogenesis Embryonic Pattern Specification Regulation Of Protein Complex Assembly Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Engulfment Of Apoptotic Cell Submandibular Salivary Gland Formation Actin Filament Branching Zygotic Specification Of Dorsal/ventral Axis Regulation Of Small GTPase Mediated Signal Transduction Anatomical Structure Development Ephrin Receptor Signaling Pathway Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Mast Cell Chemotaxis Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Palate Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Mitotic Nuclear Division	Regulation Of Apoptotic Process Regulation Of Cell Death Viral Process Negative Regulation Of Wnt Signaling Pathway Regulation Of Signal Transduction DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Negative Regulation Of Binding Regulation Of Signaling Regulation Of Wnt Signaling Pathway Signal Transduction By P53 Class Mediator Regulation Of Cellular Localization Negative Regulation Of Canonical Wnt Signaling Pathway Response To Stress Immune System Process Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of Intracellular Transport Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus Intracellular Receptor Signaling Pathway Negative Regulation Of DNA Binding Intracellular Signal Transduction Cell Cycle Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signaling Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Memory T Cell Proliferation Cell Cycle Checkpoint Cell Communication Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Positive Regulation Of Metabolic Process Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Binding Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Intracellular Protein Transport Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Fas Signaling Pathway Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint
Tagcloud ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63
Tagcloud (Difference) ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63
Tagcloud (Intersection) ?