TRIM8 and RNF141

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		TRIM8	RNF141
Gene Name		tripartite motif containing 8	ring finger protein 141
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol PML Body Intracellular Membrane-bounded Organelle
	Molecular Function	Zinc Ion Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity	DNA Binding Ubiquitin-protein Transferase Activity Zinc Ion Binding
	Biological Process	Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Viral Release From Host Cell	Regulation Of Transcription, DNA-templated Protein Autoubiquitination
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		45 interactors: BRAP CBL CCNH ITSN1 MAP3K7 MKRN3 MSL2 OTUB2 PCGF5 RAD18 RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF181 RNF41 RNF7 SIAH1 SOCS1 TNFAIP3 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UHRF2 USP2 USP21 USP39 USP7 XIAP	4 interactors: DTX3 SMURF1 TRIM24 TRIM8
Entrez ID		81603	50862
HPRD ID		06934	11509
Ensembl ID		ENSG00000171206	ENSG00000110315
Uniprot IDs		Q9BZR9	Q8WVD5
PDB IDs			2ECN
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Proteolysis Proteasomal Protein Catabolic Process Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K48-linked Ubiquitination Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Type I Interferon Production Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Protein Deubiquitination Negative Regulation Of Type I Interferon Production Immune Response Toll-like Receptor Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Protein Modification By Small Protein Removal Regulation Of Metabolic Process Negative Regulation Of Viral Release From Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K48-linked Deubiquitination Regulation Of Gene Expression Protein K63-linked Deubiquitination Cellular Process Regulation Of Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Regulation Of Vitamin D Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Cellular Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Entry Into Host Cell Protein Metabolic Process Protein Localization To Cell Surface Regulation Of Viral Entry Into Host Cell Receptor Catabolic Process Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Protein Catabolic Process Ectoderm Development Response To Organic Substance Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction Cellular Response To Stimulus Protein Export From Nucleus
Tagcloud ?		aggressive ccrcc chemotherapeutic cytotoxic defective deficit define dramatically enhancer impairing impairs inactivated inactivation link mdm2 mechanistic modulator p53 rcc re regulators renders restoring stabilizes suppress treating tumours way wild
Tagcloud (Difference) ?		aggressive ccrcc chemotherapeutic cytotoxic defective deficit define dramatically enhancer impairing impairs inactivated inactivation link mdm2 mechanistic modulator p53 rcc re regulators renders restoring stabilizes suppress treating tumours way wild
Tagcloud (Intersection) ?