NDEL1 and ANK2

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		NDEL1	ANK2
Gene Name		nudE neurodevelopment protein 1-like 1	ankyrin 2, neuronal
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Nucleolus Cytoplasm Centrosome Spindle Cytosol Kinesin Complex Microtubule Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton	Intracellular Cytosol Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Z Disc T-tubule M Band A Band Sarcolemma Neuron Projection Costamere Membrane Raft Postsynaptic Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Alpha-tubulin Binding Beta-tubulin Binding Oligopeptidase Activity	Structural Constituent Of Cytoskeleton Protein Binding Potassium Channel Regulator Activity Enzyme Binding Protein Kinase Binding Spectrin Binding Protein Binding, Bridging Ion Channel Binding ATPase Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Neuron Migration Inner Cell Mass Cell Proliferation Proteolysis Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Retrograde Axon Cargo Transport Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Activation Of Cdc42 GTPase Activity Positive Regulation Of Axon Extension Vesicle Transport Along Microtubule Positive Regulation Of Axon Regeneration Nuclear Envelope Disassembly Establishment Of Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Neuron Projection Extension	Regulation Of Heart Rate Atrial Septum Development Cellular Calcium Ion Homeostasis Axon Guidance Positive Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Paranodal Junction Assembly Regulation Of Protein Stability T-tubule Organization Protein Localization To Organelle Protein Localization To Cell Surface Cellular Protein Localization Protein Localization To M-band Protein Localization To T-tubule Positive Regulation Of Potassium Ion Transport Protein Stabilization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Methylmercury Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sarcoplasmic Reticulum Calcium Ion Transport Protein Localization To Endoplasmic Reticulum Protein Localization To Plasma Membrane Protein Targeting To Plasma Membrane Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Cardiac Muscle Cell Membrane Potential Membrane Depolarization During SA Node Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cation Channel Activity
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS			Blood trace element (Cu levels) ( 23720494) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		58 interactors: AIMP2 ANK2 APP BMI1 CCDC88A CCHCR1 CCSER1 CCSER2 CDK5 CENPF CEP170 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 GOLGA2 IMMT KALRN KIFC3 KRT40 LUC7L2 MAGEA11 MBIP MIS18A MLLT10 MRC2 MTUS2 NDC80 NDE1 PAFAH1B1 PKP2 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TRIM27 USP2 XPA YWHAE YWHAG ZNF10 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF260 ZNF264 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF844 ZNF91	12 interactors: DNAJB1 EPB42 KIAA0368 L1CAM NDEL1 NRCAM OBSCN SIGMAR1 SPTBN1 TAF9 TNIK TP53
Entrez ID		81565	287
HPRD ID		06340	00110
Ensembl ID		ENSG00000166579	ENSG00000145362
Uniprot IDs		Q9GZM8	Q01484
PDB IDs		2V66	4D8O
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Cerebral Cortex Development Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Cell Division Pallium Development Cell Cycle Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Telencephalon Development Organelle Organization Cytoskeleton Organization Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Cell Cycle Neural Precursor Cell Proliferation Microtubule-based Process Microtubule Cytoskeleton Organization Forebrain Development Regulation Of Gene Expression Cellular Process Cerebral Cortex Radially Oriented Cell Migration Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Regulation Of Heart Rate By Cardiac Conduction Organelle Localization Brain Development Neuron Migration Head Development Cerebral Cortex Cell Migration Movement Of Cell Or Subcellular Component Cell Cycle Process Mitotic Nuclear Division Establishment Of Organelle Localization Telencephalon Cell Migration Cardiac Muscle Cell Action Potential Forebrain Cell Migration Cellular Localization	Regulation Of Cellular Component Organization Regulation Of Cell Growth Membrane Organization Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cell Differentiation Generation Of Neurons Anatomical Structure Morphogenesis Multicellular Organismal Development Regulation Of Cell Morphogenesis Neurogenesis Anatomical Structure Development Regulation Of Intracellular Signal Transduction Axonogenesis Cell Morphogenesis Cell Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cellular Component Assembly Cell Projection Organization Regulation Of Growth Developmental Process Regulation Of Signal Transduction By P53 Class Mediator Neuron Projection Morphogenesis System Development Regulation Of Neurogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Component Size Regulation Of Axon Extension Neuron Projection Development Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Regulation Of Neuron Projection Development Axon Guidance Neuron Development Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Endomembrane System Organization Regulation Of Signal Transduction B Cell Differentiation Negative Regulation Of Helicase Activity Protein Localization To M-band Positive Regulation Of Cell Growth Regulation Of Cell Projection Organization Protein Import Into Nucleus Protein Localization Protein Metabolic Process Nuclear Import Neuron Differentiation
Tagcloud ?		ammonis c57bl ca3 capillary cornu dentate dg disc1 disrupted epilepsy epilepticus erk etiology gyrus hippocampus homolog hypothesize lis1 lissencephaly meanwhile microtubule mitosis organization pilocarpine schizophrenia se seizure spontaneous vessels	absent eif2alpha encode failed hela indirect inhibit insufficient interestingly k1 longer measure modest modification necessary pkr portion possesses prevented productive replicate restoration rk13 s2c theory third vaccinia virus viruses
Tagcloud (Difference) ?		ammonis c57bl ca3 capillary cornu dentate dg disc1 disrupted epilepsy epilepticus erk etiology gyrus hippocampus homolog hypothesize lis1 lissencephaly meanwhile microtubule mitosis organization pilocarpine schizophrenia se seizure spontaneous vessels	absent eif2alpha encode failed hela indirect inhibit insufficient interestingly k1 longer measure modest modification necessary pkr portion possesses prevented productive replicate restoration rk13 s2c theory third vaccinia virus viruses
Tagcloud (Intersection) ?