SHOC2 and ERBB2IP

Number of citations of the paper that reports this interaction (PMID 16301319)
24

Data Source:
HPRD (in vivo)

		SHOC2	ERBB2IP
Gene Name		soc-2 suppressor of clear homolog (C. elegans)	erbb2 interacting protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Cytoplasm	Basement Membrane Nucleus Nucleoplasm Cytoplasm Plasma Membrane Basal Plasma Membrane Cell Junction Hemidesmosome Nuclear Membrane
	Molecular Function	Protein Phosphatase Regulator Activity Protein Phosphatase Binding	ErbB-2 Class Receptor Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Ras Protein Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Regulation Of Catalytic Activity	Protein Targeting Cell Cycle Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Growth Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Pathways			Signaling by ERBB2
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP ERBB2IP HRAS KRAS NRAS RAF1	62 interactors: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 NOD2 NR2E1 PICK1 PKP4 RAF1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9
Entrez ID		8036	55914
HPRD ID		04144	06090
Ensembl ID		ENSG00000108061	ENSG00000112851
Uniprot IDs		Q9UQ13	B4DIP2 Q96RT1
PDB IDs			1MFG 1MFL 1N7T 2H3L 2QBW 3CH8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rac Protein Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Visual Learning Visual Behavior Activation Of MAPKK Activity Associative Learning Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Guidance Blood Coagulation Hemostasis Learning Insulin Receptor Signaling Pathway Axonogenesis Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Synaptic Transmission, GABAergic Wound Healing Chemotaxis Response To Fibroblast Growth Factor Regulation Of Rac Protein Signal Transduction Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Response To Wounding Epithelial Tube Branching Involved In Lung Morphogenesis Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Learning Or Memory Positive Regulation Of Ras Protein Signal Transduction Fc Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Neuronal Synaptic Plasticity Activation Of Protein Kinase Activity Innate Immune Response Signal Transduction By Phosphorylation Neuron Projection Development Response To Insulin Cognition Positive Regulation Of Small GTPase Mediated Signal Transduction	Regulation Of Signaling Response To Stimulus Response To Organic Substance Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Response To Stress Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Positive Regulation Of Cellular Biosynthetic Process Cell Junction Assembly Regulation Of Cell Proliferation SMAD Protein Complex Assembly Negative Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Movement Signal Transduction Cellular Response To Organic Cyclic Compound Organ Development Anatomical Structure Morphogenesis Cellular Component Assembly Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Renal System Development Negative Regulation Of Signaling Regulation Of Cell Motility Gastrulation Cell-cell Signaling Regulation Of Cell Differentiation Negative Regulation Of Signal Transduction Regulation Of Locomotion Response To Wounding Urogenital System Development Regulation Of Cell Migration System Development Regulation Of Epithelial Cell Proliferation Adherens Junction Organization Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Positive Regulation Of Gene Expression Response To Organic Cyclic Compound Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		aortic associates biopsies cardiac cardiomyocytes clear clearly constriction decompensated died elucidated erbb2 erbin erk explored failing heart hearts homolog hypertrophy interacting isoproterenol modulating overload participates raf rapidly soc widely	adoptive cd4 cholangiocarcinoma contained exists exomic experienced harnessed helper humans infiltrating interacting lymphocytes mediate metastatic mount mutated mutation polyfunctional prolonged pure recognizing regression retreated sequencing stabilization til transfer
Tagcloud (Difference) ?		aortic associates biopsies cardiac cardiomyocytes clear clearly constriction decompensated died elucidated erbin erk explored failing heart hearts homolog hypertrophy isoproterenol modulating overload participates raf rapidly soc widely	adoptive cd4 cholangiocarcinoma contained exists exomic experienced harnessed helper humans infiltrating lymphocytes mediate metastatic mount mutated mutation polyfunctional prolonged pure recognizing regression retreated sequencing stabilization til transfer
Tagcloud (Intersection) ?		erbb2 interacting