HDAC11 and PHYHIP

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HDAC11	PHYHIP
Gene Name		histone deacetylase 11	phytanoyl-CoA 2-hydroxylase interacting protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Histone Deacetylase Activity Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Oligodendrocyte Development Chromatin Modification Histone Deacetylation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Height ( 20881960)	Hypertriglyceridemia ( 23505323)
Protein-Protein Interactions		5 interactors: CDKN1A HDAC6 MAPK6 NELFCD PHYHIP	24 interactors: BAI1 C14orf1 COPS6 DYRK1A EEF1A1 FAM131A HDAC11 HNRNPA1 MAGED4B MED8 METTL18 NDRG1 NDUFV3 NFE2 PHYH PNPLA2 PPIE PRMT5 S100A13 SMARCC2 SUPT5H TTR WDR89 ZZEF1
Entrez ID		79885	9796
HPRD ID		09146	16345
Ensembl ID		ENSG00000163517	ENSG00000168490
Uniprot IDs		B5MCQ6 E7ETT9 Q96DB2	Q92561
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Heat Response To Heat Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Hsp90 Deacetylation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Polyubiquitinated Misfolded Protein Transport Response To Toxic Substance Response To Temperature Stimulus Cellular Response To Extracellular Stimulus Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Intestinal Epithelial Cell Maturation Aggresome Assembly Cellular Response To UV-B Tubulin Deacetylation Positive Regulation Of Oxidative Stress-induced Cell Death Peptidyl-lysine Deacetylation Cellular Response To Misfolded Protein Positive Regulation Of Receptor Biosynthetic Process Regulation Of Hydrogen Peroxide Metabolic Process Stress-induced Premature Senescence Response To Misfolded Protein Regulation Of Hydrogen Peroxide-induced Cell Death Response To Extracellular Stimulus Misfolded Or Incompletely Synthesized Protein Catabolic Process Regulation Of Microtubule-based Movement Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Arrest Regulation Of Receptor Biosynthetic Process Response To UV-B Intestinal Epithelial Cell Development Regulation Of Protein Import Into Nucleus, Translocation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Androgen Receptor Signaling Pathway Intestinal Epithelial Cell Differentiation Epithelial Cell Maturation Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Cell Death Histone H4 Deacetylation Negative Regulation Of Oxidoreductase Activity Response To Arsenic-containing Substance Regulation Of Establishment Of Protein Localization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Metabolic Process Cellular Senescence Regulation Of Response To Reactive Oxygen Species Negative Regulation Of Microtubule Depolymerization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Nucleosome Disassembly Chromatin Organization Mast Cell Activation MRNA Processing RNA Metabolic Process Cellular Metabolic Process MRNA Metabolic Process MRNA Splicing, Via Spliceosome Interleukin-1 Alpha Secretion RNA Splicing, Via Transesterification Reactions Gene Expression RNA Processing Chromosome Organization Chromatin Modification Positive Regulation Of Viral Process Nucleobase-containing Compound Metabolic Process Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Methyl-branched Fatty Acid Metabolic Process Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Splicing Glial Cell Development Peripheral Nervous System Development Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Involved In Forebrain Neuron Fate Commitment Acylglycerol Acyl-chain Remodeling Thyroid Hormone Transport Isoprenoid Metabolic Process Fatty Acid Alpha-oxidation Interleukin-1 Secretion Positive Regulation Of Spindle Checkpoint Regulation Of RNA Metabolic Process
Tagcloud ?		acetylation acetyltransferases atf2 chip d54mg deacetylase erythematosus favoring gcn5 globally h4 h4ac h4k12 h4k16 h4k5 h4k8 hdac3 imbalance irf1 k12 k16 k8 look lupus monocytes overexpressing pcaf seq sle
Tagcloud (Difference) ?		acetylation acetyltransferases atf2 chip d54mg deacetylase erythematosus favoring gcn5 globally h4 h4ac h4k12 h4k16 h4k5 h4k8 hdac3 imbalance irf1 k12 k16 k8 look lupus monocytes overexpressing pcaf seq sle
Tagcloud (Intersection) ?