SHFM1 and PCID2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (x-ray crystallography, affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		SHFM1	PCID2
Gene Name		split hand/foot malformation (ectrodactyly) type 1	PCI domain containing 2
Image
Gene Ontology Annotations	Cellular Component	Proteasome Complex Integrator Complex	Cellular_component
	Molecular Function	Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination	Negative Regulation Of Apoptotic Process Regulation Of MRNA Stability Positive Regulation Of B Cell Differentiation Positive Regulation Of Transcription, DNA-templated Spleen Development Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Cysteine-type Endopeptidase Activity
Pathways
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 20732625) Immunoglobulin A ( 20694011)
Protein-Protein Interactions		7 interactors: BRCA1 BRCA2 MAP1LC3B NUDT21 PCID2 PSMD3 PSMD6	3 interactors: EID1 IKZF3 SHFM1
Entrez ID		7979	55795
HPRD ID		03182	07749
Ensembl ID			ENSG00000126226
Uniprot IDs		P60896 Q6IBB7	Q5JVF3
PDB IDs		1IYJ 1MIU 1MJE 3T5X	3T5X
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Arrest Regulation Of Cell Cycle Regulation Of Cell Cycle Arrest Regulation Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Protein Ubiquitination DNA Damage Checkpoint Protein Polyubiquitination Cellular Response To Stress Regulation Of Protein Ubiquitination Cell Cycle Checkpoint Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Process Negative Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process Centrosome Cycle Programmed Cell Death Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cell Death Death Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Ligase Activity Negative Regulation Of Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		10q24 17p13 cgh cnvs congenital deletions dlx5 duplications dync1i1 eexons encompassing enhancer enhancers exonic exons families foot fourth hearing hs1642 kb malformation microdeletions split syndromic telomeric tp63 unrelated	associates balance blastocyst block cbp collectively degraded developmental e3 eid1 embryonic esc escs hallmarks hat impede k48 lethality ligase maintenance mdm2 modulation pluripotency renewal self suppression sustain switch ubiquitination
Tagcloud (Difference) ?		10q24 17p13 cgh cnvs congenital deletions dlx5 duplications dync1i1 eexons encompassing enhancer enhancers exonic exons families foot fourth hearing hs1642 kb malformation microdeletions split syndromic telomeric tp63 unrelated	associates balance blastocyst block cbp collectively degraded developmental e3 eid1 embryonic esc escs hallmarks hat impede k48 lethality ligase maintenance mdm2 modulation pluripotency renewal self suppression sustain switch ubiquitination
Tagcloud (Intersection) ?