DNALI1 and EPS8

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DNALI1	EPS8
Gene Name		dynein, axonemal, light intermediate chain 1	epidermal growth factor receptor pathway substrate 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Axonemal Dynein Complex Axoneme Filopodium	Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Growth Cone Vesicle Stereocilium Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Microtubule Motor Activity Protein Binding Dynein Heavy Chain Binding	Actin Binding SH3/SH2 Adaptor Activity Protein Binding Rac GTPase Binding
	Biological Process	Movement Of Cell Or Subcellular Component Single Fertilization Metabolic Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Adult Locomotory Behavior Regulation Of Cell Shape Positive Regulation Of Signal Transduction Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility
Pathways
Drugs
Diseases
GWAS			Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		6 interactors: ABCF3 APP EPS8 HTT PRMT6 SIAH1	54 interactors: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BYSL C17orf59 C19orf25 C8orf33 CASK CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RFXAP RUNX1T1 SCRN3 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XRCC6 ZZZ3
Entrez ID		7802	2059
HPRD ID		03681	02563
Ensembl ID		ENSG00000163879	ENSG00000151491
Uniprot IDs		B4DHN6 O14645	B4DX66 B4E3T6 Q12929
PDB IDs			2E8M
Enriched GO Terms of Interacting Partners?		Neuron Apoptotic Process Neuron Death Locomotory Behavior Axon Cargo Transport Mating Visual Learning Visual Behavior Single-organism Behavior Associative Learning Movement Of Cell Or Subcellular Component Neural Plate Formation Behavior Adult Locomotory Behavior Regulation Of Receptor Activity Response To External Stimulus Microtubule-based Transport Histone H3-R2 Methylation Synaptic Growth At Neuromuscular Junction Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Learning Cytoskeleton-dependent Intracellular Transport Transition Metal Ion Homeostasis Sexual Reproduction Adult Behavior Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Actin Polymerization-dependent Cell Motility Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Collateral Sprouting In Absence Of Injury Regulation Of Protein Phosphatase Type 2A Activity Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Neuron Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Lactate Biosynthetic Process Neuron Development Apoptotic Process Programmed Cell Death Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Paraxial Mesoderm Formation Reproduction Cell Death Death Exit From Mitosis Axon Choice Point Recognition Quinolinate Metabolic Process Cellular Response To CGMP Response To Stimulus	Cell Differentiation Developmental Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development System Development Anatomical Structure Development Cell Projection Morphogenesis Cell Part Morphogenesis Axonogenesis Axon Guidance Fc Receptor Signaling Pathway Axon Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Neuron Projection Development Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Organelle Organization Positive Regulation Of Signal Transduction Cell Morphogenesis Leukocyte Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Development Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of ERBB Signaling Pathway Nervous System Development Innate Immune Response Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorylation Regulation Of Immune System Process Platelet Activation Response To Fibroblast Growth Factor
Tagcloud ?		affymetrix anxa2 axonemal call carefully cytoskeleton discoveries dissected dynein endosomal exploration frontotemporal ftld inclusions insoluble landmark lobar mnd mortem myd88 networks neurodegenerative pgrn progranulin qrt sorting synapse u ubiquitinated	adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound
Tagcloud (Difference) ?		affymetrix anxa2 axonemal call carefully cytoskeleton discoveries dissected dynein endosomal exploration frontotemporal ftld inclusions insoluble landmark lobar mnd mortem myd88 networks neurodegenerative pgrn progranulin qrt sorting synapse u ubiquitinated	adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound
Tagcloud (Intersection) ?