PRDM2 and HIST3H3

Number of citations of the paper that reports this interaction (PMID 14633678)
29

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		PRDM2	HIST3H3
Gene Name		PR domain containing 2, with ZNF domain	histone cluster 3, H3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus	Nucleosome Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Zinc Ion Binding Histone-lysine N-methyltransferase Activity	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone Lysine Methylation	Telomere Maintenance
Pathways			DNA Damage/Telomere Stress Induced Senescence Meiotic recombination Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Mitotic Prophase formation of the beta-catenin:TCF transactivating complex Cellular Senescence Meiotic synapsis Signaling by Wnt Cell Cycle, Mitotic M Phase Telomere Maintenance Packaging Of Telomere Ends TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: E2F1 ESR1 HIST1H3A HIST3H3 RB1	183 interactors: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BIRC5 BMI1 BPTF BRD7 C11orf30 C17orf49 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CCDC101 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK CREBBP CTBP1 CTBP2 DEK DIDO1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPK HNRNPL HNRNPR ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2A KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 NAP1L4 NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 ORC2 ORC3 ORC4 ORC5 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRKCZ PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TDRD3 TNPO1 TRPM7 UHRF1 VPRBP WHSC1 ZMYM4 ZNF217 ZNF516
Entrez ID		7799	8290
HPRD ID		03120	04156
Ensembl ID		ENSG00000116731	ENSG00000168148
Uniprot IDs		Q13029 Q5THJ1	Q16695
PDB IDs		2JV0 2QPW	2V1D 2YBP 2YBS 3A6N 3T6R
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Chromosome Organization Negative Regulation Of Gene Expression Positive Regulation Of Fibroblast Proliferation Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Fibroblast Proliferation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Chromatin Organization Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation G1/S Transition Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Chromatin Remodeling Regulation Of Centromere Complex Assembly Prostate Epithelial Cord Elongation Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Maintenance Of Mitotic Sister Chromatid Cohesion Lens Fiber Cell Apoptotic Process Regulation Of Cohesin Localization To Chromatin Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Attachment Of Mitotic Spindle Microtubules To Kinetochore Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Anoikis Organelle Organization Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy Homeostatic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Gene Expression Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Peptidyl-amino Acid Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Protein Acetylation Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Regulation Of Cellular Process Metabolic Process Histone H3 Acetylation Histone Lysine Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Peptidyl-lysine Methylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression
Tagcloud ?		arid1a ash1l atlas broadly chd6 colorectal concordant copy ep300 ep400 exome gains hypermutation mismatch mll2 mll3 nonhypermutated preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta trrap uncertain validating	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Difference) ?		arid1a ash1l atlas broadly chd6 colorectal concordant copy ep300 ep400 exome gains hypermutation mismatch mll2 mll3 nonhypermutated preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta trrap uncertain validating	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Intersection) ?