ZNF227 and UMPS

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ZNF227	UMPS
Gene Name		zinc finger protein 227	uridine monophosphate synthetase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Cytosol
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding	Orotate Phosphoribosyltransferase Activity Orotidine-5'-phosphate Decarboxylase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Pyrimidine Nucleobase Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process UMP Biosynthetic Process Female Pregnancy Lactation Cellular Response To Drug 'de Novo' UMP Biosynthetic Process Small Molecule Metabolic Process Pyrimidine Nucleoside Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Generic Transcription Pathway	Pyrimidine biosynthesis Pyrimidine metabolism Metabolism of nucleotides
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CDKN2A CEP70 CSNK1E GSK3B RPS6KA6 UMPS	10 interactors: A2M CALU CDC42EP3 DLST NOS3 PAXIP1 PLA2G12A PSEN1 RPS29 ZNF227
Entrez ID		7770	7372
HPRD ID		15752	02022
Ensembl ID		ENSG00000131115
Uniprot IDs		B7Z5P9 B7Z6M2 Q86WZ6	A8K5J1 B5LY70 P11172
PDB IDs			2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ 3EX1 3EX2 3EX3 3EX4 3EX6 3G3D 3G3M 3L0K 3L0N 3MI2 3MO7 3MW7 4HIB 4HKP
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Export From Nucleus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Proteolysis Cell Cycle Process Negative Regulation Of Phosphorylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Phosphate-containing Compound Metabolic Process Cell Cycle Cellular Response To Stress G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Cell-matrix Adhesion Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteolysis Mitotic Cell Cycle Process Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Phosphorylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of MAPK Cascade Re-entry Into Mitotic Cell Cycle Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Neuron Maturation 'de Novo' UMP Biosynthetic Process Circadian Rhythm Hypermethylation Of CpG Island Positive Regulation Of Cellular Senescence Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Negative Regulation Of Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell-substrate Adhesion Regulation Of Nucleocytoplasmic Transport Cellular Response To Interleukin-3 Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Protein Kinase Activity Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Mesoderm Development Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Neuron Maturation Negative Regulation Of Signal Transduction	Exocytosis Platelet Degranulation Cajal-Retzius Cell Differentiation Positive Regulation Of Histone H3-K36 Methylation Beta-amyloid Formation Catabolic Process Endothelial Cell Migration Intracellular Signal Transduction Blood Coagulation Hemostasis Extracellular Matrix Disassembly Epithelial Cell Migration Epithelium Migration Smooth Muscle Hyperplasia Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Complement Activation, Lectin Pathway Secretion By Cell Blood Vessel Development Cellular Amino Acid Catabolic Process Vasculature Development Cellular Nitrogen Compound Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Regulation Of Body Fluid Levels Smooth Muscle Adaptation Synaptic Vesicle Targeting Regulation Of Resting Membrane Potential Wound Healing Secretion Negative Regulation Of Muscle Hyperplasia Regulation Of Systemic Arterial Blood Pressure By Endothelin Nitrogen Compound Metabolic Process Positive Regulation Of Protein Complex Assembly Cell Activation Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Choline Transport Ameboidal-type Cell Migration Response To Wounding Platelet Activation Regulation Of Protein Ubiquitination Carboxylic Acid Catabolic Process Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Catalytic Activity Lysine Catabolic Process Arginine Catabolic Process Chorion Development Amyloid Precursor Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Cell Migration Positive Regulation Of Guanylate Cyclase Activity
Tagcloud ?			acrofacial arch auxotrophic biallelic biosynthesis bud cad complementation dho dhodehase dhodh dihydroorotate discrepancies discrepant dysostosis exceptional genee miller mim missense novo oa orotic pharyngeal postaxial predicts pyrimidine requirement weidemann
Tagcloud (Difference) ?			acrofacial arch auxotrophic biallelic biosynthesis bud cad complementation dho dhodehase dhodh dihydroorotate discrepancies discrepant dysostosis exceptional genee miller mim missense novo oa orotic pharyngeal postaxial predicts pyrimidine requirement weidemann
Tagcloud (Intersection) ?