TRIM26 and USP39

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		TRIM26	USP39
Gene Name		tripartite motif containing 26	ubiquitin specific peptidase 39
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol	Spliceosomal Complex
	Molecular Function	DNA Binding Zinc Ion Binding Metal Ion Binding	Zinc Ion Binding Ubiquitinyl Hydrolase Activity
	Biological Process	Cytokine-mediated Signaling Pathway Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Viral Release From Host Cell	Spliceosomal Complex Assembly MRNA Processing Ubiquitin-dependent Protein Catabolic Process Cell Cycle RNA Splicing Cell Division
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Schizophrenia ( 21926974 22883433)
Protein-Protein Interactions		15 interactors: AES MNAT1 OTUB2 PHF7 RABEP1 RNF10 RNF126 THAP1 TRIM41 UBE2D1 UBE2D2 UBE2D3 USP36 USP39 USP5	11 interactors: ACVR1 APP SAE1 SP1 SRPK1 TRAF6 TRIM25 TRIM26 TRIM39 TRIM5 TRIM8
Entrez ID		7726	10713
HPRD ID		02901	07165
Ensembl ID		ENSG00000234127	ENSG00000168883
Uniprot IDs		Q12899	B3KMG1 B7Z7L9 Q53GS9
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Ubiquitination Proteolysis Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Catabolic Process Protein Polyubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Protein Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Deubiquitination Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Protein K48-linked Deubiquitination Protein Modification By Small Protein Removal Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Transcription Initiation From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Innate Immune Response Regulation Of Proteasomal Protein Catabolic Process Protein Monoubiquitination DNA-templated Transcription, Initiation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Innate Immune Response Response To Hypoxia Cytoplasm-associated Proteasomal Ubiquitin-dependent Protein Catabolic Process BMP Signaling Pathway RNA Metabolic Process Transcription, DNA-templated Cellular Response To Stress Regulation Of Protein Catabolic Process RNA Biosynthetic Process	Negative Regulation Of Viral Release From Host Cell Regulation Of Viral Process Negative Regulation Of Viral Entry Into Host Cell Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Process Regulation Of Viral Release From Host Cell Defense Response Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Immune Response Cellular Response To Interferon-gamma Immune System Process Cellular Protein Modification Process Response To Interferon-gamma Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cytokine-mediated Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Metabolic Process Negative Regulation Of Locomotion Cellular Response To Cytokine Stimulus Regulation Of Signal Transduction Cellular Response To Organic Substance Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cellular Protein Metabolic Process Response To Cytokine Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of RNA Metabolic Process Response To Stress Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance Regulation Of Lipopolysaccharide-mediated Signaling Pathway Atrial Septum Development Signal Transduction Regulation Of Activin Receptor Signaling Pathway Protein Metabolic Process Viral Process Signaling Cell Communication Protein K63-linked Ubiquitination Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process
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