XRCC4 and CAAP1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		XRCC4	CAAP1
Gene Name		X-ray repair complementing defective repair in Chinese hamster cells 4	caspase activity and apoptosis inhibitor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Centrosome Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Cell Junction DNA Ligase IV Complex Nonhomologous End Joining Complex
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Ligase Activity
	Biological Process	In Utero Embryonic Development Pro-B Cell Differentiation DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Central Nervous System Development Response To X-ray Response To Gamma Radiation Viral Process T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Establishment Of Integrated Proviral Latency	Apoptotic Process
Pathways		HIV Life Cycle Nonhomologous End-joining (NHEJ) HIV Infection Integration of provirus Double-Strand Break Repair 2-LTR circle formation Early Phase of HIV Life Cycle
Drugs		S-(Dimethylarsenic)Cysteine
Diseases
GWAS		Hypertension ( 21626137)
Protein-Protein Interactions		19 interactors: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 FAM9B GZMB IFFO1 LIG4 NBN NHEJ1 PNKP PRKDC VIM	4 interactors: APP KAT7 PTN XRCC4
Entrez ID		7518	79886
HPRD ID		15951	12981
Ensembl ID		ENSG00000152422	ENSG00000120159
Uniprot IDs		Q13426 Q7Z763	Q9H8G2
PDB IDs		1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Polynucleotide 3' Dephosphorylation Single Strand Break Repair Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Apoptotic Process Programmed Cell Death Cellular Response To Stress B Cell Activation Cell Death Death Pro-B Cell Differentiation Cell Activation Immunoglobulin Production Response To Radiation Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination DNA Recombination Lymphoid Progenitor Cell Differentiation Response To Stress DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Protein Autophosphorylation Regulation Of Voltage-gated Calcium Channel Activity DNA Catabolic Process Response To Ionizing Radiation Isotype Switching Lymphocyte Activation T Cell Differentiation V(D)J Recombination Mitotic Cell Cycle Checkpoint Regulation Of Protein Autophosphorylation Cellular Response To Stimulus Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Leukocyte Activation Regulation Of Cell Cycle Process Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Cycle Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Central Nervous System Development Response To Stimulus Regulation Of Cell Death Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Learning Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Learning Or Memory Collateral Sprouting Axon Midline Choice Point Recognition Cognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Pro-B Cell Differentiation Axon Choice Point Recognition Establishment Of Integrated Proviral Latency Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuron Remodeling Immunoglobulin V(D)J Recombination Establishment Of Viral Latency Histone H4-K12 Acetylation DNA Ligation Involved In DNA Repair Lymphoid Progenitor Cell Differentiation Response To Radiation Single-organism Behavior Histone H4-K5 Acetylation Histone H4-K8 Acetylation DNA Ligation Cellular Response To Lithium Ion Cellular Copper Ion Homeostasis Nervous System Development Behavior Double-strand Break Repair Via Nonhomologous End Joining Copper Ion Homeostasis Suckling Behavior Regulation Of Catalytic Activity Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Isotype Switching Cell Activation V(D)J Recombination Neuron Maturation MRNA Polyadenylation Response To Lithium Ion Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Neurogenesis Response To X-ray Mating Behavior Somatic Recombination Of Immunoglobulin Gene Segments Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Negative Regulation Of Catalytic Activity Somatic Diversification Of Immunoglobulins Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cell Proliferation
Tagcloud ?		annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc5 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Difference) ?		annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc5 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Intersection) ?