WNT1 and FZD8

Number of citations of the paper that reports this interaction (PMID 15454084)
100

Data Source:
HPRD (in vivo)

		WNT1	FZD8
Gene Name		wingless-type MMTV integration site family, member 1	frizzled class receptor 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface	Golgi Apparatus Plasma Membrane Integral Component Of Membrane
	Molecular Function	Frizzled Binding Cytokine Activity Protein Domain Specific Binding Transcription Regulatory Region DNA Binding Receptor Agonist Activity	G-protein Coupled Receptor Activity Receptor Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process	Embryonic Axis Specification Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Phosphorylation Cell-cell Signaling Myoblast Fusion Positive Regulation Of Cell Proliferation Response To Wounding Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell-substrate Adhesion Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Diencephalon Development Central Nervous System Morphogenesis Cerebellum Formation Forebrain Anterior/posterior Pattern Specification Midbrain-hindbrain Boundary Maturation During Brain Development Negative Regulation Of Cell-cell Adhesion Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Midbrain Development Organ Regeneration T Cell Differentiation In Thymus Inner Ear Morphogenesis Signal Transduction In Response To DNA Damage Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Neuron Fate Determination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Spemann Organizer Formation Canonical Wnt Signaling Pathway Bone Development Positive Regulation Of Dermatome Development Hepatocyte Differentiation Cellular Response To Peptide Hormone Stimulus Hematopoietic Stem Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Aging Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis G-protein Coupled Receptor Signaling Pathway Neuron Differentiation T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Transcriptional regulation of white adipocyte differentiation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors) PCP/CE pathway	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		9 interactors: FZD8 FZD9 LRP5 LRP6 PORCN RYK SFRP1 SFRP2 WNT3A	5 interactors: GOPC LRP5 LRP6 RYK WNT1
Entrez ID		7471	8325
HPRD ID		01276	05852
Ensembl ID			ENSG00000177283
Uniprot IDs		P04628	Q9H461
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Canonical Wnt Signaling Pathway Axis Elongation Involved In Somitogenesis Non-canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Axis Elongation Regulation Of Fat Cell Differentiation Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Convergent Extension Anterior/posterior Pattern Specification Somitogenesis Stem Cell Proliferation Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Somite Development Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Post-anal Tail Morphogenesis Regulation Of Phosphorylation Immune System Development Regulation Of Embryonic Development Segmentation Regulation Of Protein Kinase Activity Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Regulation Of Kinase Activity Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Regulation Of Phosphorus Metabolic Process Epithelial Tube Morphogenesis Negative Regulation Of Protein Serine/threonine Kinase Activity Developmental Growth Involved In Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Stem Cell Differentiation Tube Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Pattern Specification Process Regulation Of Organ Morphogenesis Regulation Of Bone Remodeling Morphogenesis Of An Epithelium Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Organ Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Ossification Regulation Of Protein Phosphorylation Mesenchyme Development Neural Crest Formation	Wnt Signaling Pathway Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Axis Specification Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Fat Cell Differentiation Midbrain-hindbrain Boundary Development Positive Regulation Of Wnt Signaling Pathway Embryonic Retina Morphogenesis In Camera-type Eye Cell Migration Involved In Gastrulation Rostrocaudal Neural Tube Patterning Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Canonical Wnt Signaling Pathway Bone Development Dorsal/ventral Axis Specification Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Anterior/posterior Pattern Specification Regulation Of Wnt Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Embryonic Organ Morphogenesis Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Bone Remodeling Embryonic Eye Morphogenesis Regulation Of Mesenchymal Cell Proliferation Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Signal Transduction Epithelial Tube Morphogenesis Cerebellum Morphogenesis Regulation Of Phosphorylation Hindbrain Morphogenesis Gastrulation With Mouth Forming Second Retina Morphogenesis In Camera-type Eye Bone Remodeling Tube Morphogenesis Negative Regulation Of Fat Cell Differentiation Embryonic Camera-type Eye Development Neural Tube Patterning Forebrain Development Cell Differentiation Response To Peptide Hormone Mammary Gland Duct Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of Tissue Remodeling Pattern Specification Process Response To Peptide Embryonic Organ Development Gland Development
Tagcloud ?		access acid breaks chromosome cloning embryonic experiments inducible karyotypes late lines morphologies morphology neurogenesis observing p19 placed produced responsive resulting retinoic see sequences transcribed undifferentiated useful variety wide would	aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd5 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Difference) ?		access acid breaks chromosome cloning embryonic experiments inducible karyotypes late lines morphologies morphology neurogenesis observing p19 placed produced responsive resulting retinoic see sequences transcribed undifferentiated useful variety wide would	aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd5 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Intersection) ?