VAV2 and VCPIP1

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		VAV2	VCPIP1
Gene Name		vav 2 guanine nucleotide exchange factor	valosin containing protein (p97)/p47 complex interacting protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Cytoplasm Endoplasmic Reticulum Golgi Stack
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding	Ubiquitin-specific Protease Activity
	Biological Process	Angiogenesis Signal Transduction Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Regulation Of Gene Expression Cell Migration Lamellipodium Assembly Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Rho GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Proteolysis Mitotic Nuclear Division Endoplasmic Reticulum Membrane Fusion Protein Ubiquitination Protein K11-linked Deubiquitination Protein K48-linked Deubiquitination Golgi Reassembly
Pathways		Signaling by GPCR Axon guidance L1CAM interactions FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Rho GTPase cycle DAP12 signaling EPH-ephrin mediated repulsion of cells VEGFR2 mediated vascular permeability EPH-Ephrin signaling G alpha (12/13) signalling events Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Signalling by NGF DAP12 interactions Signal transduction by L1 Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling GPCR downstream signaling Signaling by VEGF NRAGE signals death through JNK Signaling by Rho GTPases GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Multiple sclerosis ( 20598377) vWF and FVIII levels ( 21810271)
Protein-Protein Interactions		62 interactors: ARIH1 BIRC6 BOD1L1 BRDT BZW1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 FNTA FUCA1 FYN GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MARCH7 MED21 MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1	7 interactors: FCHSD2 SMAD9 STX5 UBC VAV2 VCP WAC
Entrez ID		7410	80124
HPRD ID		02694	15645
Ensembl ID		ENSG00000160293	ENSG00000175073
Uniprot IDs		P52735	Q96JH7
PDB IDs		2DLZ 2DM1 2LNW 2LNX
Enriched GO Terms of Interacting Partners?		Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Fibroblast Growth Factor Phosphatidylinositol-mediated Signaling Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Growth Factor Response To Organic Substance Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Platelet Activation Innate Immune Response Regulation Of Cellular Protein Metabolic Process Cellular Protein Modification Process Cellular Metabolic Process Protein Metabolic Process Positive Regulation Of Viral Process Regulation Of Body Fluid Levels Wound Healing Immune Response Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Cell Activation Regulation Of Signal Transduction Response To Wounding Regulation Of Signaling Intracellular Signal Transduction Regulation Of T Cell Activation Viral Process Positive Regulation Of Signal Transduction Blood Coagulation Cell Surface Receptor Signaling Pathway Hemostasis Protein Ubiquitination Regulation Of Immune System Process Signal Transduction Regulation Of Intracellular Signal Transduction Chemotaxis Positive Regulation Of Homotypic Cell-cell Adhesion	Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process G1 DNA Damage Checkpoint ER To Golgi Vesicle-mediated Transport Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Histone H2B Conserved C-terminal Lysine Ubiquitination Protein Ubiquitination Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Protein Modification By Small Protein Conjugation Positive Regulation Of Cell Death Response To Stress Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Golgi Disassembly Cellular Response To DNA Damage Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Metabolic Process Endosomal Transport Neurotrophin TRK Receptor Signaling Pathway Retrograde Protein Transport, ER To Cytosol Apoptotic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cell Cycle Checkpoint Programmed Cell Death Regulation Of Protein Deubiquitination Protein Processing Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Death Death Response To Organic Substance Protein Hexamerization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Abiotic Stimulus
Tagcloud ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?